药理和非药理治疗疼痛糖尿病外围神经病变的方法
Han Na Jang1, Tae Jung Oh1,2
1Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Diabetes & metabolism journal
|September 6, 2023
概括
糖尿病外围神经病变 (DPN) 疼痛显著影响生活质量. 目前的治疗重点是使用已批准的药物和新兴疗法 (如脊髓刺激) 进行症状管理.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 疼痛管理 疼痛管理
背景情况:
- 糖尿病外围神经病变 (DPN) 是一种常见的糖尿病并发症.
- 疼痛性DPN影响15-25%的糖尿病患者,降低了他们的生活质量.
- 单独控制高血糖症往往不足以控制DPN疼痛.
研究的目的:
- 审查目前对疼痛性DPN的药理和非药理治疗方法.
- 要突出FDA批准的药物和治疗疼痛DPN的疗法.
- 为DPN提供疼痛管理策略的概述.
主要方法:
- 对神经性疼痛的药理疗法的文献综述.神经性疼痛.
- 包括FDA批准的治疗疼痛性DPN的药物.
- 非药物干预的描述,包括脊髓刺激.
主要成果:
- 已建立的药物类别包括 gabapentinoids,SNRIs,TCAs,α-lipoic acid,通道阻断剂和局部素.
- 美国食品和药物管理局批准的疼痛性DPN治疗方法包括pregabalin,duloxetine,tapentadol,8%的素补丁和脊髓刺激.
- 由于缺乏修改疾病的DPN药物,疼痛管理至关重要.
结论:
- 疼痛性DPN的有效管理需要解决高血糖症和神经病痛.
- 有一系列的药理和非药理选择可用于疼痛的DPN治疗.
- 像脊髓刺激这样的新兴疗法为管理DPN疼痛提供了新的途径.
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