孕产妇周产压力轨迹和负面影响以及幼儿桃体发育
Mollie C Marr1, Alice M Graham1, Eric Feczko1
1Department of Behavioral Neuroscience (Marr, Graham, Sturgeon, Schifsky, Fair) and Department of Psychiatry (Graham, Fair), Oregon Health and Science University School of Medicine, Portland; Department of Psychiatry, Massachusetts General Hospital, Boston (Marr); Department of Psychiatry, McLean Hospital, Belmont, Mass. (Marr); Masonic Institute for the Developing Brain, Institute of Child Development (Fair), and Department of Pediatrics (Feczko, Fair), University of Minnesota, Minneapolis; Department of Psychology and Speech-Language Pathology, University of Turku, Turku, Finland (Nolvi, Korja); Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin (Nolvi, Entringer, Buss); Department of Neuroscience, Earlham College, Richmond, Ind. (Thomas); Development, Health, and Disease Research Program and Departments of Pediatrics, Psychiatry and Human Behavior, Obstetrics and Gynecology, and Epidemiology, University of California, Irvine, School of Medicine, Irvine (Rasmussen, Entringer, Wadhwa, Buss); Department of Pediatrics, University of California, Irvine, School of Medicine, Orange (Rasmussen, Entringer, Wadhwa, Buss); Departments of Psychiatry and Human Behavior (Entringer, Wadhwa), Obstetrics and Gynecology (Wadhwa), and Epidemiology (Wadhwa), University of California, Irvine, School of Medicine, Orange; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku (Korja, H. Karlsson, L. Karlsson); Centre for Population Health Research, University of Turku and Turku University Hospital (Korja, H. Karlsson, L. Karlsson); Department of Paediatrics and Adolescent Medicine (L. Karlsson) and Department of Psychiatry (H. Karlsson), Department of Clinical Medicine, Turku University Hospital and University of Turku; Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill (Gilmore); Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill (Styner).
怀孕期间母亲的压力模式会影响婴儿的大脑发育和行为. 具体来说,在怀孕晚期增加的压力与婴儿的消极影响和新生儿杏仁体连接的改变有关.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 怀孕期间母亲的心理压力是众所周知的后代精神疾病的风险因素.
- 对于不同母亲的压力模式 (轨迹) 如何影响婴儿大脑系统和行为的理解有限.
- 这项研究解决了关于母亲压力轨迹的异质性及其对发育影响的知识差距.
研究的目的:
- 研究怀孕期间不同母亲压力轨迹与婴儿行为现象型之间的关系.
- 探索母亲的压力模式与新生儿大脑功能连接之间的联系,特别是在与负面影响相关的系统中.
主要方法:
- 在两个独立的母婴队列中,在怀孕期间在多个时间点评估了母亲的焦虑,压力和抑郁.
- 检查了与婴儿负面影响有关的母亲压力轨迹.
- 在一个子集中利用新生儿桃体休息状态功能连接性MRI来探索大脑系统的关联.
主要成果:
- 确定了四个不同的母体压力轨迹集群和两个大小集群.
- 妊娠后期增加母亲压力的轨迹与婴儿负面影响的减弱有关,在更大的队列中复制.
- 妊娠后期增加或达到峰值的孕产妇压力的轨迹与新生儿桃体与前侧胰岛和中腹前额皮层的功能连接性更强相关.
结论:
- 怀孕期间母亲压力的特定轨迹显著影响后代的大脑和行为发展.
- 了解母亲压力模式的异质性对于开发针对婴儿神经发育的有针对性的干预措施至关重要.
- 研究结果强调了母亲压力的时间和模式对婴儿结果的重要性.
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