在非糖尿病妇女中,母亲的妊娠体重增加和不良妊娠结果
Binbin Yin1, Lingwei Hu2, Kaiqi Wu1
1Department of Clinical Laboratory, The Women's Hospital of Zhejiang University School of Medicine, Hangzhou, P.R. China.
概括
母胎妊娠期体重增加 (GWG) 显著影响怀孕结果. 即使没有妊娠期糖尿病 (GDM),过度的GWG也会增加巨症的风险,并且对妊娠年龄的婴儿来说很大.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 公共卫生 公共卫生
背景情况:
- 孕期糖尿病 (GDM) 是一个已知的妊娠不良结果的风险因素.
- 有限的研究集中在孕期体重增加 (GWG) 对GDM阴性孕妇的影响上.
- 阴性GDM女性可能会被忽视,可能导致过度GWG和相关风险.
研究的目的:
- 研究母亲GWG与没有GDM的妇女不良妊娠结果之间的关联.
- 为了比较与GWG相关的风险,GDM阴性女性与GDM阳性女性.
- 探索妊娠前体重指数 (pp-BMI) 对这些关联的影响.
主要方法:
- 对30910名孕妇进行的回顾性队列研究 (2017年7月~2020年1月).
- 参与者按GWG (不充分,充分,过度) 和GDM状态分类.
- 用GDM阳性人群作为参考;根据pp-BMI分析子组.
主要成果:
- 不足够,充足和过度的GWG群体显示,宏观体的发病率越来越高,并且对于妊娠年龄 (LGA) 很大.
- 与GDM阳性女性相比,GDM阴性女性的过度GWG存在较高的宏观症和LGA风险.
- 不足够的GWG与不考虑pp-BMI的早产风险有关;SGA风险与不足够的GWG和低pp-BMI (<18.5 kg/m2) 相关.
结论:
- 不适当的GWG,不充分和过度,与GDM阴性妇女的不良妊娠结果密切相关.
- 具有不适当GWG的GDM阴性女性需要专注的产前照顾和管理.
- 临床策略应包括所有孕妇的体重管理,咨询和目标设定,无论GDM状态如何.
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