休息状态网络中的功能性改变,用于帕金森病中的心理理论
Giuseppe Rabini1, Giulia Funghi1, Claudia Meli1
1Center for Mind/Brain Sciences, University of Trento, Trento, Italy.
The European journal of neuroscience
|September 6, 2023
概括
心理理论 (ToM) 网络连接在帕金森病 (PD) 中发生变化. 早期的PD显示连接性下降,而长期的PD显示了整个ToM网络的连接性增加,影响了认知和情感功能.
科学领域:
- 神经科学是一个神经科学.
- 认知神经学 认知神经学
背景情况:
- 在帕金森病 (PD) 中,越来越多地认识到心智理论 (ToM) 的障碍.
- 在PD中ToM网络功能连接的具体变化尚不清楚.
研究的目的:
- 调查PD患者和健康对照 (HC) 之间的ToM网络中的功能连接差异.
- 检查疾病持续时间如何影响PD中ToM网络内的功能变化.
主要方法:
- 分析了四组休息状态功能磁共振成像 (rs-fMRI) 数据:短期PD (PD-1),长期PD (PD-2) 和他们各自的健康对照 (HC-1,HC-2).
- 在ToM网络的情感,认知和核心子网络之间评估了连接性.
主要成果:
- 与HC-1相比,PD-1患者在ToM网络内表现出功能连接性下降,主要影响认知和情感子网络.
- 与PD-1和HC-2患者相比,PD-2患者在ToM网络中显示出功能连接性增加,核心子网络的变化不那么一致.
结论:
- 在帕金森病中,ToM网络中的功能连接发生了显著的变化.
- 这些变化遵循一个渐进的模式:早期PD的连接性下降,在后期发展到广泛的连接性增加.
- 认知和情感ToM子网络都参与了这些与疾病相关的功能变化.
相关概念视频
Neural Regulation
39.5K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.5K
Parkinson's Disease: Overview
593
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
593
Parkinson's Disease: Treatment
295
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
295


