抗体属性,Fc受体表达,妊娠和母体SARS-CoV-2感染调节HSV IgG的胎盘转移
Aakash Mahant Mahant1, Fatima Estrada Trejo1, Jennifer T Aguilan1
1Departments of Microbiology and Immunology, Obstetrics-Gynecology and Women's Health, and Biochemistry Albert Einstein College of Medicine, Bronx, NY 10461, USA.
iScience
|September 6, 2023
概括
孕产妇的抗体调解了对新生儿疹的保护. 母亲的SARS-CoV-2感染增加了ADCC介导IgG的转移,可能增强对单纯疹病毒 (HSV) 的保护.
科学领域:
- 免疫学 免疫学 免疫学
- 周围生理学 周围生理学
- 病毒学 病毒学
背景情况:
- 抗体依赖细胞细胞毒性 (ADCC) 对于预防新生儿疹至关重要.
- 简单疹病毒 (HSV) 免疫球蛋白G (IgG) 在这种保护中起作用.
- 影响HSV IgG的胎盘转移的因素,包括SARS-CoV-2感染,尚未完全理解.
研究的目的:
- 调查抗原标,功能,甘氨酸,妊娠年龄和母体SARS-CoV-2感染对ADCC介导的HSV IgG的胎盘转移的影响.
- 为了比较 HSV IgG 转移在流行病前和流行病前的队列.
主要方法:
- 在COVID-19大流行之前和期间,从HSV阳性母体收集了母体和带血液样本.
- 分析HSV特异性IgG亚类,中和活性,ADCC活性,Fc受体亲和力和甘氨酸配置文件.
- 评估转移比率 (TR) 和胎盘FcRn和FcγRIIIa的局部化.
主要成果:
- 在早产的婴儿中, HSV 中和性IgG 转移比早产的婴儿低 (TR 0.84 与 2.44).
- 在疫情前,在术期和早产婴儿中,ADCC介导的IgG转移<1.0.
- 抗甘氨酸蛋白D IgG (仅中和) 和抗甘氨酸蛋白B (gB) IgG (中和和ADCC) 显示出不同的Fc受体亲属性和甘氨酸形状.
- 孕产妇的SARS-CoV-2感染显著增加了ADCC介导的IgG转移,与增强的FcRn-FcγRIIIa胎盘局部化有关.
结论:
- 妊娠年龄和IgG功能 (中和与ADCC) 影响胎盘转移.
- SARS-CoV-2 感染可能会增强期婴儿中ADCC介导的HSV IgG的胎盘转移.
- 这些发现为制定预防新生儿疹的策略提供了洞察力.
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