口腔炎症负荷预测年轻成年人群的血管功能:试点研究
Ker-Yung Hong1, Avin Ghafari1, Yixue Mei1
1Department of Kinesiology, Faculty of Science, McMaster University, Hamilton, ON, Canada.
Frontiers in oral health
|September 6, 2023
概括
通过口腔炎症负荷 (OIL) 测量轻度口腔炎症,预测健康成年人的血管功能下降. 这表明,保持口腔健康可能对心血管健康很重要.
科学领域:
- 心血管生理学心血管生理学
- 口腔健康研究研究 口腔健康研究
- 内皮细胞功能 内皮细胞功能
背景情况:
- 牙周是高度血管化的,牙周炎会对血管系统产生负面影响.
- 轻度口腔炎对健康个体心血管功能的影响尚不清楚.
- 这项试点研究调查了全口口腔炎症负荷 (OIL) 对血管功能的影响.
研究的目的:
- 为了研究客观测量整个口腔口腔炎症负荷 (OIL) 对血管功能的影响.
- 为了确定OIL是否预测健康成年人的血压变化,动脉硬或内皮功能.
主要方法:
- 对28名全身健康的年轻成年人 (18-30岁) 的横截面,相关性分析.
- 口服炎症负荷 (OIL) 用口服中性粒细胞计数从口腔冲洗样本量化.
- 通过血压,脉冲波速度 (动脉硬) 和流量介导扩张 (内皮功能) 评估血管功能.
主要成果:
- 口服中性粒细胞计数显著预测流媒体扩张减少 (p=0.04,R2=0.16).
- 与较低OIL (10.0±5.2%,p=0.05) 相比,具有较高OIL (>2.5×105中性粒细胞) 的参与者表现出较低的流媒体扩张 (6.0±2.3%).
- 没有发现动脉硬的显著预测因素.
结论:
- 口腔炎症负荷 (OIL) 是内皮功能受损的预测指标,以减少流媒体扩张为标志.
- 流媒体扩张障碍是未来心血管疾病的潜在危险因素.
- 这项研究强调了口腔健康的重要性,并表明OIL可能会影响内皮功能.
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