总麻醉改变了中枢神经系统和活动依赖和活动独立基因的天体细胞表达
Zoeb Jiwaji1,2,3,4, Nóra M Márkus1,2, Jamie McQueen1,2
1UK Dementia Research Institute, Edinburgh Medical School, The University of Edinburgh, Edinburgh, United Kingdom.
Frontiers in network physiology
|September 6, 2023
概括
全身麻醉抑制大脑活动并改变基因表达,可能损害大脑健康,特别是在老年人或痴呆症患者中. 这项研究揭示了麻醉的影响超出了抑制活动的范围,诱导炎症和反应性星球细胞.
科学领域:
- 神经科学是一个神经科学.
- 麻醉学 麻醉学
- 分子生物学分子生物学
背景情况:
- 全身麻醉是常见的,但可能会导致长期的中枢神经系统 (CNS) 副作用,特别是在弱势群体,如老年人或痴呆症患者.
- 神经元活动对大脑健康至关重要,其抑制是麻醉引起的无意识的标志.
- 除了简单的活动抑制之外,麻醉对大脑基因调节的全部影响仍然不清楚.
研究的目的:
- 调查全身麻醉对皮质基因表达的综合影响.
- 为了确定麻醉诱导的基因表达变化是否仅仅是由于抑制的神经元活动.
- 检查全身麻醉对天体细胞基因表达特征的具体影响.
主要方法:
- 在体内全身麻醉后皮质基因表达变化的分析.
- 与体外研究中的基因表达模式进行比较,这些研究涉及完全阻断神经元发射.
- 聚焦分析星细胞基因表达变化对麻醉的反应.
主要成果:
- 全身麻醉降低了大脑皮层中活动依赖基因的表达.
- 麻醉诱导的基因表达模式与神经保护抑制和亡促进有关,反映了完全的神经元不活动.
- 麻醉还触发了与炎症和细胞死亡相关的非活动调节基因.
- 星球细胞表现出基因表达的变化,表明活性低和反应状态低,类似于中风和神经炎症等疾病.
结论:
- 一般麻醉对皮质基因表达的影响与大脑活动的显著抑制一致.
- 麻醉除了抑制活动之外还会产生额外的有害影响,包括炎症和细胞死亡途径.
- 总麻醉促进了反应性星球细胞的形状,这表明它对大脑健康有不利影响,特别是在易受伤害的个体中.
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