年龄,身体组成参数和血糖控制比疾病活动更有助于肌骨评分的恶化
Ivana Ságová1,2, Marián Mokáň2, Ingrid Tonhajzerová3
1Department of Endocrinology, National Institute of Endocrinology and Diabetology, Ľubochňa, Slovakia.
Frontiers in endocrinology
|September 6, 2023
概括
壮症患者的骨微架构 (骨骨分) 比健康个体差,不论骨矿物质密度如何. 年龄和腰围显著预测这种骨结构衰退.
科学领域:
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
- 医疗成像医学成像
背景情况:
- 巨症是一种多余生长激素的状况,与骨结构的改变有关.
- 骨矿物质密度 (BMD) 可能无法完全捕捉壮症骨质损伤的程度.
- 在壮症中,身体组成的变化会影响骨强度.
研究的目的:
- 为了评估 BMD 和 腰椎椎骨分数 (TBS) 在壮病患者.
- 调查TBS与疾病活动,年龄,葡萄糖代谢和身体组成之间的关系.
- 为了比较TBS和骨质疏松症患者和健康对照组之间的骨质疏松症和骨质疏松症.
主要方法:
- 对115名壮病患者和78名匹配的健康对照进行了横截面研究.
- 双能X射线吸收计 (DXA) 用于测量BMD,TBS和身体组成.
- 统计分析包括相关性和多重线性回归.
主要成果:
- 宏壮病患者的TBS明显低于对照组 (P<0.001).
- 年龄,腰围,脂肪量,瘦肉量和糖化血红蛋白与TBS负相关.
- 年龄和腰围是TBS在壮症的独立预测因素.
- 在骨质疏松症患者和对照人群之间,或在活跃和受控疾病之间,在骨质疏松症患者和对照人群之间的骨质疏松症没有显著差异.
结论:
- 巨症与不良的骨微架构 (下TBS) 相关,不论BMD.
- 诸如年龄,身体组成和葡萄糖代谢等因素,而不是疾病活动,是骨结构恶化的关键驱动因素.
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