NK细胞治疗对肺癌继发性败血症的影响:一个病例报告
Jingling Tang1, Lulu Xie2, Honglin Liu3
1Clinical Research Center, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, China.
Open life sciences
|September 6, 2023
概括
当抗生素失败时,全基性自然杀手 (NK) 细胞输液对患有瘤相关性败血症的患者显示了暂时的益处. 实验室研究表明NK细胞功能可能受到患者血清因素的限制,这表明潜在的预测生物标志物.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 关键护理医学 关键护理医学
背景情况:
- 败血症存在高死亡风险,需要新的治疗策略.
- 接受广泛治疗的癌症患者容易发生败血症.
- 传统的败血症治疗,包括抗生素,在复杂的病例中可能是无效的.
研究的目的:
- 评估全基性自然杀手 (NK) 细胞输液作为瘤相关败血症的实验性治疗的疗效.
- 在这种情况下,研究NK细胞输注的治疗效果和局限性的机制.
- 探索体外共同培养试验在预测治疗反应方面的潜力.
主要方法:
- 向患有状细胞癌的男性患者注射全源天然杀手 (NK) 细胞,该患者在治疗后出现了败血症.
- 输液后监测临床状态,感染标志物和细胞因子 (炎症和抗瘤) 概况.
- 在体外研究涉及患者血清和NK细胞产品,以评估NK细胞功能和细胞因子调节.
主要成果:
- 在NK细胞输注后,患者意识暂时改善,感染标志物减少.
- 血清分析显示抑制的炎症性细胞因子 (例如,白内素-6) 和高的抗瘤细胞因子.
- 在体外实验表明,患者血清抑制了NK细胞的细胞毒性活动,并降低了关键杀死分子的调节.
结论:
- 在与瘤相关的败血症患者中,采用异构NK细胞的转移可能会提供症状缓解.
- 患者血清成分可能会对全原NK细胞功能产生负面影响,限制治疗时间.
- 在体外共同培养试验表明,作为预测性生物标志物,对全原NK细胞治疗在败血症中的有效性有希望.
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