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克罗恩病是非酒精性脂肪性肝病的较大危险因素,而不是性结肠炎:系统性审查
Athri Kodali1, Chiugo Okoye1, Dhadon Klein2
1Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.
Cureus
|September 6, 2023
概括
克罗恩病 (CD) 患者患非酒精性脂肪性肝病 (NAFLD) 的风险高于性结肠炎 (UC) 患者. 这一系统性审查强调了在CD个体中早期监测和预防NAFLD的必要性.
科学领域:
- 胃肠病学和肝病学
- 内部医学 内部医学
- 公共卫生 公共卫生
背景情况:
- 炎症性肠道疾病,包括克罗恩病 (CD) 和性结肠炎 (UC),与非酒精性脂肪性肝病 (NAFLD) 有关.
- 了解CD和UC之间的NAFLD比较风险对于患者管理至关重要.
研究的目的:
- 系统地审查和比较患有克罗恩病 (CD) 和性结肠炎 (UC) 的患者非酒精性脂肪性肝病 (NAFLD) 的患病率和风险.
主要方法:
- 对2000年1月至2023年5月期间发表的观察性研究进行了全面的系统审查.
- 通过电子数据库搜索确定了研究,并使用纽卡斯尔-太华尺度评估了质量.
- 综合了来自10项研究的数据 (4164名参与者),遵循PRISMA 2020指南.
主要成果:
- 全球地区的NAFLD患病率在克罗恩氏病患者中较高 (中位数为37.22%),与性结肠炎患者相比 (中位数为27.55%).
- 北美,欧洲和亚洲的子组分析证实,与CD相关的NAFLD风险始终较高.
- 报告的NAFLD比例因地区而异,表明生活方式,遗传学和环境因素的影响.
结论:
- 与性结肠炎患者相比,克罗恩病患者的非酒精性脂肪肝疾病风险明显更高.
- 在CD的跨体炎症可能会导致像NAFLD这样的代谢异常.
- 早期NAFLD监测和量身定制的预防策略对于克罗恩病患者至关重要.
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