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较高的体重指数是发展抗脂抗体综合征的危险因素吗?
Eman M Mansory1,2, Atheer M Badawi3, Renad Rajab3
1Department of Hematology, King Abdulaziz University, Jeddah, SAU.
Cureus
|September 6, 2023
概括
在这项研究中,较高的体重指数 (BMI) 不被发现是抗脂抗体 (aPLs) 阳性的危险因素. 需要进一步的研究来了解肥胖和aPLs之间的关系.
科学领域:
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
- 流行病学 流行病学
背景情况:
- 抗脂抗体 (aPLs) 与临床条件相关,但也可以无症状.
- 一般人口的1-5%可能有无临床表现的aPLs.
研究的目的:
- 调查身体质量指数 (BMI) 与抗脂抗体 (aPLs) 阳性的频率之间的相关性.
- 为了确定高BMI是否是aPLs阳性的风险因素.
主要方法:
- 从第三级中心 (2010-2020年) 获得的aPL测试数据的回顾性分析.
- 将患者分为BMI组的分类:<25,25-30和>30.
- 统计分析包括千平方,费舍尔的确切测试,两个样本的t测试和多变量逻辑回归,根据年龄,血栓形成史,妊娠并发症和自身免疫性疾病进行调整. 性行为被分析为一种效果修饰剂.
主要成果:
- 在312名患者中,aPL阳性率为20.8% (体重指数<25),13.0% (体重指数25-30),18.4% (体重指数>30).
- 多变量逻辑回归表明,与BMI <25 (或BMI 25-30的0.55,或BMI >30的0.76) 相比,高BMI组的aPL阳性风险较低的趋势,但这些发现没有统计学意义 (p=0.116和p=0.46,分别).
结论:
- 较高的BMI似乎不是抗脂抗体 (aPLs) 阳性的重要危险因素.
- 肥胖和抗脂抗体之间的复杂相互作用需要进一步研究.
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