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人类百菌病:来自印度北部高等保健中心的观察性研究
Renu Kumari1, Raj Kumar Kalyan1, Asmat Jahan1
1Department of Microbiology, King George's Medical University, Lucknow, IND.
Cureus
|September 6, 2023
概括
这项研究发现,抗布鲁塞拉IgM ELISA比IgG ELISA更准确地检测人类血病. 动物产品的消费和与动物的接触是布鲁塞拉感染的关键风险因素.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 动物传播感染 动物传播感染
背景情况:
- 血病是一种被忽视的动物性传染病,由于慢性疾病和治疗费用,其经济影响很大.
- 关节疼痛,表现为关节痛或关节炎,是人类牛肉的一个常见的临床表现.
- 在印度北部,对菌病的研究有限,这突显了区域知识差距.
研究的目的:
- 在患有关节疼痛的患者中检测和描述布鲁塞拉菌种.
- 调查研究群体中与人类血病相关的潜在原因和危险因素.
- 评估血清学和分子方法的诊断准确性,用于检测血病.
主要方法:
- 在两年内 (2019年9月至2021年9月) 从患有关节疼痛的患者收集了200个血液样本.
- 采用血清学测试,包括抗布鲁塞拉IgM和IgG酶相关的免疫吸收试验 (ELISA).
- 利用分子诊断技术,如逆转录酶-聚合酶连锁反应 (RT-PCR) 和常规聚合酶连锁反应 (PCR),以及自动化血液培养系统.
主要成果:
- 抗布鲁塞拉IgM ELISA检测出9.5%的阳性,而抗布鲁塞拉IgG ELISA显示出11.5%的阳性;0.5%对两者都呈阳性.
- 在IgM阳性样本中,4%通过PCR/RT-PCR确认阳性,IgG ELISA阴性.
- 自动化血液培养系统对所有测试患者产生了负面结果.
结论:
- 与抗布鲁塞拉IgG ELISA相比,抗布鲁塞拉IgM ELISA在诊断人类乳病方面表现出更高的准确性.
- 发现布鲁塞拉感染的主要危险因素包括动物产品 (牛奶,乳制品,肉类) 的消费和与动物的直接接触.
- 乳头菌仍然是一个重大的公共卫生问题,需要改进诊断和预防策略,特别是在印度北部等地区.
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