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Updated: Jul 17, 2025

Comparative Lesions Analysis Through a Targeted Sequencing Approach
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在同步结肠癌中使用循环瘤DNA测序检测到BRAF突变异质性:一个案例报告

Haruka Kono1, Taro Yamanaka1, Yuki Nishihara2

  • 1Department of Medical Oncology, Toranomon Hospital, Tokyo, Japan.

Cancer diagnosis & prognosis
|September 6, 2023
PubMed
概括

同步结直肠癌可以显示病变之间的遗传差异. 复发期间的液体活检显示了BRAF突变,解释了这种情况下的治疗耐药性和转移.

关键词:
同步结肠癌是同步的结肠癌.循环瘤DNA (ctDNA) 的发生.病毒性瘤基因同类B1 (BRAF) 突变的v-raf小鼠肉瘤.

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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