乳腺癌中的自性向纳米颗粒:系统性审查
Asal Golchin1, Masoumeh Maleki2, Forough Alemi2
1Department of Clinical Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Cell biology international
|September 6, 2023
概括
自由纳米颗粒可以通过影响癌症治疗中的关键过程自,从而影响癌症细胞死亡. 本综述探讨了各种纳米颗粒如何诱导或抑制自,为新的乳腺癌治疗策略提供了见解.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 癌症研究 癌症研究
背景情况:
- 乳腺癌仍然是女性癌症死亡的主要原因,治疗耐药性是一个重大挑战.
- 瘤对治疗的耐药性通常与亡 (编程细胞死亡) 的缺陷有关.
- 自,一种替代性的细胞死亡途径,提出了一个潜在的策略,以增强癌症细胞死亡和克服抵抗.
研究的目的:
- 研究自由 (没有药物载荷) 纳米颗粒在调节乳腺癌细胞自的作用.
- 评估纳米粒子诱导或抑制自对乳腺癌治疗的影响.
- 在乳腺癌模型中系统地审查有关纳米粒子-自相互作用的现有文献.
主要方法:
- 对符合纳入标准的25篇文章进行系统审查.
- 分析使用MCF-7,MDA-MB-231,MDA-MB-468,SUM1315和4T1乳腺癌细胞系的研究.
- 包括在体外和体外/体外研究中使用各种自细胞检测方法 (Acridine orange,Western blot,Cyto-ID,共聚焦显微镜,qPCR) 的研究.
主要成果:
- 研究了各种纳米粒子 (Ag,Au,Y2O3,Se,ZnO,CuO,Al,Fe,氧化物,脂质体) 对它们对自的作用.
- 大多数金属纳米粒子 (36%) 诱导了自,主要是通过反应性氧物种 (ROS) 介导的途径.
- 只有16%的研究涉及PI3K/Akt/mTOR和MAPK/ERK信号通路;31%的研究没有调查NP相关的自道.
结论:
- 自由纳米颗粒对自产生多种影响,包括诱导和抑制,影响乳腺癌治疗.
- 通过ROS介导的途径是纳米粒子诱导自的常见机制.
- 需要进一步的研究来充分阐明纳米粒子-自相互作用及其治疗潜力,特别是关于特定的信号通路.
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