生殖因素和女性视角开放玻璃眼的风险
Jia-Yan Kai1, Miao Zhou1,2,3, Dan-Lin Li1
1School of Public Health, Suzhou Medical College of Soochow University.
Journal of glaucoma
|September 6, 2023
概括
晚期初潮和早期更年期等生殖因素增加了开角玻璃眼 (OAG) 的风险. 五次或更多分娩的病史也会增加女性的OAG风险.
科学领域:
- 眼科和生殖健康 眼科和生殖健康
背景情况:
- 人们越来越认识到生殖因素对各种健康结果的潜在影响.
- 女性生殖特征与患开角玻璃眼 (OAG) 风险之间的关联需要进一步研究.
研究的目的:
- 系统地审查和元分析关键女性生殖因素与患开角玻璃眼的风险之间的关联.
- 研究初潮时的年龄,更年期的年龄,生殖期和对OAG风险的平价的影响.
主要方法:
- 在主要数据库 (PubMed,Embase,Cochrane,Web of Science) 进行了全面的文献搜索,截至2022年2月.
- 使用固定效应模型,从符合条件的研究中对调整后的赔率比率 (ORs) 的元分析.
- 进行了剂量反应分析,以探索因素与OAG风险之间的连续关系.
主要成果:
- 晚期初潮 (≥13年) 与OAG风险增加1.76倍有关.
- 早期更年期 (<45岁) 显著增加了OAG风险 (OR=1.89).
- 高均值 (≥5名儿童) 与2.35倍高的OAG风险有关,观察到J形剂量反应关系.
结论:
- 晚期初潮,早期更年期和高平价率 (≥5次分娩) 被确定为开角玻璃眼的潜在风险因素.
- 建议进行进一步的纵向研究,以阐明生殖因素与OAG发展之间的复杂关系.
相关概念视频
Open Angle Glaucoma: Treatment
477
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
477
Glaucoma: Overview
619
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
619
Angle Closure Glaucoma: Treatment
560
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
560
Oogenesis
63.8K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.8K
Photoreceptors and Visual Pathways
6.1K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.1K


