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饥饿选择减少并延迟了幼虫的ecdysone生产和信号传递

Jennifer M Clark¹, Allen G Gibbs¹

¹School of Life Sciences, University of Nevada, Las Vegas, 4505 S. Maryland Pkwy, Las Vegas, NV 89154-4004, USA.

The Journal of experimental biology

|September 6, 2023

概括

果的饥饿选择导致发育延迟和脂肪储存增加,因为它减少了生态类固醇激素的产生. 这种发育迟缓会影响成年人对饥饿的抵抗力.

科学领域:

发育生物学是发展生物学.
内分泌学在内分泌学.
遗传学遗传学是一个

背景情况:

在Drosophila melanogaster中选择抗饥饿的选择导致化延迟和增加成人脂肪储存.
连接饥饿选择压力与这些表型变化的潜在机制在很大程度上是未知的.

研究的目的:

调查饥饿选择影响Drosophila melanogaster发育时间和脂肪储存的机制.
确定ecdysteroid信号在调解饥饿选择效应中的作用.

主要方法:

在饥饿选择 (SS) 和食控制 (FC) 群体之间对幼虫和幼发育时间的比较分析.
酶免疫试验用于量化SS和FC中的ecdysteroid水平 (20-hydroxyecdysone和α-ecdysone).
通过补充α-ecdysone来对幼虫食进行实验性操纵,以评估救援效应.

主要成果:

在SS群体中,在幼虫发育过程中脂肪储存增加,幼虫和幼发育延长,以及与ecdysteroid脉冲相关的发育检查点延迟.
与FC相比,SS群体中证实了减少和延迟的ecdysteroid生产.
用α-ecdysone补充剂部分挽救了发育迟缓,但也减少了成人饥饿抵抗力.

结论:

在Drosophila melanogaster中,饥饿选择诱导了幼虫阶段减少和延迟的ecdysteroid产量.
这种荷尔蒙变化会影响发育时间,有助于观察到成年人脂肪储存的增加和增强的饥饿抵抗力.

关键词:

身体大小身体尺寸埃克迪索尼是一种Ecdysone.进化进化进化进化进化进化进化胖胖胖的胖胖的胖胖的幼虫的发展幼虫的发展饥饿饥饿饥饿饥饿饥饿

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