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蛋白质组学阐明了TDP-43的生理和病理功能

Jorge García Morato1, Christian Johannes Gloeckner2,3, Philipp J Kahle1,4

  • 1Laboratory of Functional Neurogenetics, Department of Neurodegeneration, German Center of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

Proteomics
|September 6, 2023
PubMed
概括

43kDa的转激活反应DNA结合蛋白 (TDP-43) 形成了各种蛋白质复合体,对细胞功能至关重要. 了解TDP-43的使用情况

关键词:
处理RNA处理RNA的过程在TDP-43中使用.互动的作用组.液态-液态相隔离方法 液态相隔离方法

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Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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