尿道膀癌分子亚型中的转移和复发模式
Gottfrid Sjödahl1,2, Pontus Eriksson3, Karin Holmsten4,5
1Department of Translational Medicine, Lund University, Malmö, Sweden.
International journal of cancer
|September 6, 2023
概括
尿道膀癌的分子亚型表现出特定的转移部位偏好. 了解这些模式可以指导针对晚期膀癌的向治疗.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症转移 癌症转移
背景情况:
- 膀的尿路癌通常会转移到淋巴结,肺,肝脏和骨.
- 存在分子分类分类学,但子类型的器官特异性热带性仍然不清楚.
研究的目的:
- 调查原发性尿路膀癌分子亚型与远程转移部位之间的关联.
- 为了确定特定的分子亚型是否对特定的器官表现出热带性.
主要方法:
- 对146名患有新发转移性疾病或复发的患者的分析.
- 使用转录组方法和免疫染色方法对原发性瘤进行分子分类.
- 变试验用于识别分子亚型中转移性位点的丰富和枯竭.
主要成果:
- 基底/状亚型显示骨转移枯竭,而尿状亚型显示骨转移丰富.
- 基因组不稳定的亚型缺少肺转移,但富含异常部位,包括大脑转移.
- 富有肌瘤的瘤与局部复发相关,而不是远程转移;化疗方案影响了大脑/丸转移率.
结论:
- 尿道膀癌的分子亚型与特定的转移部位有显著的关联.
- 这些关联表明存在影响转移级联的亚型特定分子决定因素.
- 这些发现可能会为转移性膀癌的亚型特定治疗策略提供信息.
相关概念视频
02:30Metastasis
5.6K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.6K
02:07Tumor Progression
6.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.4K