相关实验视频
Updated: Jul 17, 2025

12:31
An Ex vivo Model to Study Hormone Action in the Human Breast
Published on: January 8, 2015
11.5K
缺乏证据表明,排卵周期中的孕会导致乳腺癌
A Gompel1, V Seifert-Klauss2, J A Simon3
1Gynecology-Endocrinology, Paris-Cité University, Paris, France.
Climacteric : the journal of the International Menopause Society
|September 6, 2023
概括
这篇评论质疑说孕激素分泌会导致乳腺癌的说法,理由是缺乏突变性证据和原始文章关于其在癌症发展中的作用的论点中的不一致性.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 生殖生物学 生殖生物学
背景情况:
- 最近的一篇观点文章提出,在排卵周期期间的孕分泌是乳腺癌的原因.
- 本评论批判性地评估了上述文章中提出的证据.
研究的目的:
- 挑战孕激素是乳腺癌的直接原因的说法.
- 为了解决关于孕激素在乳腺癌起源中的作用的具体争论点.
主要方法:
- 在最初的视角文章中提出的证据的逐一反驳.
- 分析现有的关于孕激素的突变性和癌症中的作用的文献.
- 在特定的妇科条件下讨论荷尔蒙的影响.
主要成果:
- 没有证据表明孕激素在乳腺细胞中的突变性.
- 基于周期期间与怀孕期间的孕激素暴露的致癌作用的归因不一致.
- 孕激素与与降低乳腺癌风险相关的特定遗传突变之间的可疑联系.
结论:
- 孕激素与乳腺癌风险增加之间的假设联系是不令人信服的.
- 需要进一步的研究来澄清激素和乳腺癌之间的复杂关系.
- 原文的证据不充分支持其关于孕激素诱导的乳腺癌的说法.
相关概念视频
Ovarian Cycle
1.3K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
1.3K
Hormonal Control of the Ovarian Cycle
565
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
565
Hormonal Regulation of the Menstrual Cycle
435
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
435
Disorders of the Female Reproductive System
405
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
405
Oogenesis
63.8K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.8K
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K

