与肥胖相关的人类lncRNA AATBC刺激脂肪细胞中的线粒体功能
Maude Giroud1,2,3,4, Stefan Kotschi4, Yun Kwon1,2,3
1Institute for Diabetes and Cancer, Helmholtz Center Munich, Neuherberg, Germany.
EMBO reports
|September 6, 2023
概括
长非编码RNA AATBC 调节脂肪细胞的可塑性,增强热生成功能和线粒体健康. 这一发现为代谢调节和肥胖提供了新的见解.
科学领域:
- 代谢调节和脂肪细胞生物学.
- 能量平衡的分子机制.
背景情况:
- 脂肪细胞功能障碍是肥胖相关疾病的核心.
- 热源性脂肪细胞促进心脏代谢健康.
- 脂肪细胞的可塑性,即能够在白色和热原体表型之间切换的能力,是代谢适应的关键.
研究的目的:
- 为了确定脂肪细胞可塑性的新型调节剂.
- 研究 lncRNA AATBC 在人类脂肪细胞功能中的作用.
- 探索AATBC,新陈代谢和肥胖之间的联系.
主要方法:
- 人类脂肪组织和培养脂肪细胞的比较转录概况.
- 使用初级和永生的人类脂肪细胞的功能研究.
- 在体内对小鼠进行的研究表明,AATBC在脂肪组织中表达.
- 在人类受试者的相关性分析.
主要成果:
- 在热生成条件下,AATBC富含,并增强热生成脂肪细胞表型.
- AATBC促进了细胞呼吸和线粒体分裂的增加.
- 在小鼠脂肪组织中AATBC的表达会降低血瘦素水平.
- 人体脂肪组织的AATBC水平与血瘦素,BMI和代谢健康标志物相反相关.
结论:
- AATBC是脂肪细胞可塑性的特定人体调节剂.
- AATBC影响线粒体功能和热生成.
- AATBC是一种影响人类代谢健康的新型肥胖相关因素.
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