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Updated: Jul 17, 2025

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通过诱导IGF2BP3 / FOXO1 / JAK2 / STAT3通路介导的ROS生产,威他费林A抑制了肝细胞癌的进展

Jinhai Li1, Mengchen Ge2, Pengcheng Deng2

  • 1Department of Hepatobiliary Surgery, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Immunopharmacology and immunotoxicology
|September 6, 2023
PubMed
概括

维他费林A (WA) 通过增加活性氧物种 (ROS),抑制IGF2BP3和禁用JAK2/STAT3信号,从而抑制肝细胞癌 (HCC) 的生长,从而导致FOXO1.1.3的增加. 这揭示了HCC的新治疗途径.

关键词:
这就是FOXO1的意义.在 IGF2BP3BP3 中.在JAK2/STAT3信号系统中,可以使用JAK2/STAT3信号.这就是ROSOS ROS.在Withaferin A中使用A.肝细胞癌是肝细胞癌.

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