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甲状腺Print®:对于无限期甲状腺细胞学的临床实用性

Roberto Olmos¹, José Miguel Domínguez¹, Sergio Vargas-Salas²

¹Department of Endocrinology, School of Medicine Pontificia Universidad Católica de Chile.

Endocrine-related cancer

|September 6, 2023

概括

甲状腺Print®分子检测有助于医生避免不必要的手术,因为不确定的甲状腺结节 (ITNs). 这项研究表明,它在ITN患者中减少了67%的诊断手术,有利于积极监测良性结果.

科学领域:

内分泌学在内分泌学.
在瘤学瘤学.
分子诊断学分子诊断

背景情况:

不确定的甲状腺结节 (ITNs) 带来了诊断挑战,通常需要手术来排除恶性瘤.
分子测试提供了一个潜在的解决方案,以改善ITN诊断和指导临床决策.
甲状腺Print®是一种十基因分类器,旨在识别良性ITN,减少侵入性手术的需要.

研究的目的:

评估ThyroidPrint®对ITN患者医生决策的临床效用和影响.
评估ThyroidPrint®在减少ITN诊断手术中的实际有效性.
为了确定手术确诊病例中的良性呼叫率 (BCR) 和恶性瘤率.

主要方法:

进行了一项前性,单中心,非干预性临床实用性研究.
在 ThyroidPrint® 测试之前和之后,分析了医生关于 ITN 管理的决定.
收集的数据包括结节的特征,分子测试结果,BCR和手术中的基因病理结果.

主要成果:

该研究包括1272个精细针的愿望,其中109个 (8.6%) 是贝塞斯达III和135个 (10.6%) 是贝塞斯达IVITNs.
对155个ITN进行了分子测试,结果为67.1%的良性呼叫率 (BCR).
医生选择在99%的患有良性甲状腺打印®结果的患者中进行主动监测,为ITNs减少了67%的诊断手术.

结论:

甲状腺Print® 有效地帮助医生管理不确定的甲状腺结节,显著降低诊断手术的速度.
分子分类器在指导临床决策方面具有很高的实用性,促进对良性分类结节的积极监测.
这项研究证实了ThyroidPrint®在优化ITN患者护理方面的实际临床益处.

关键词:

临床实用性的临床实用性遗传分类器遗传分类器不确定的甲状腺细胞学

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