在急性髓性白血病中补充维生素C和维生素D
Pierre Luc Mouchel1,2,3, Emilie Bérard4,5, Suzanne Tavitian1
1Centre Hospitalier Universitaire de Toulouse, Institut Universitaire du Cancer de Toulouse Oncopole, Service d'Hématologie, Toulouse, France.
Blood advances
|September 6, 2023
概括
维生素C和维生素D补充剂对于接受化疗的急性髓性白血病 (AML) 患者是安全的. 补充改善了维生素D水平和减少了感染,特别有利于NPM1突变患者获得更好的整体存活率.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 营养科学 营养科学
背景情况:
- 急性髓性白血病 (AML) 是一种复杂的血液性恶性瘤.
- 维生素C和维生素D在AML支持性护理中的作用正在研究中.
- 临床实践在2018年发生了变化,包括为AML患者补充维生素C和维生素D.
研究的目的:
- 为了比较AML患者的治疗结果,有和没有维生素C和维生素D补充剂.
- 评估维生素C和维生素D在AML强化化疗中的安全性和有效性.
- 研究补充剂对感染率,反应,复发和存活率的影响.
主要方法:
- 这是一项回顾性研究,比较了431名AML患者 (2015-2020年).
- 262名患者没有接受补充剂;169人接受了维生素C和维生素D.
- 维生素从化疗的第10天开始服用,直到血液恢复.
主要成果:
- 维生素C/D组在诱导后和移植前显示出显著增加的维生素D水平.
- 在维生素C/D组中观察到较低的细菌/真菌感染,出血和MAS的发病率.
- 在NPM1突变患者中,维生素C/D补充与更好的整体存活率独立相关.
结论:
- 维生素C和维生素D补充剂对于接受密集化疗的AML患者是安全的.
- 补充剂可能会影响结果,特别是NPM1-突变AML的整体存活率.
- 需要进一步的研究来证实这些发现,并优化维生素补充方案.
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