结合BAL和计算机断层扫描,区分了渐进性和非渐进性纤维化肺部疾病
Joseph L Barnett1, Toby M Maher2, Jennifer K Quint3
1Department of Radiology, Royal Free Hospital, London, United Kingdom.
American journal of respiratory and critical care medicine
|September 6, 2023
概括
识别肺纤维化 (PF) 进展是管理的关键. 结合BAL和CT扫描有助于预测PF进展,BAL淋巴细胞瘤表明特定患者群体的风险较低.
科学领域:
- 肺部病理学 肺部病理学
- 放射学 放射学是一门学科.
- 免疫学 免疫学 免疫学
背景情况:
- 肺纤维化 (PF) 的进展难以预测,影响患者的管理.
- 早期识别风险患者对于及时干预至关重要.
- 结合支气管支气管洗 (BAL) 和计算机断层扫描 (CT) 可以改善预后.
研究的目的:
- 评估基线BAL和CT发现在区分渐进型和非渐进型PF的综合实用性.
- 通过成像和细胞数据识别PF进展的预测因素.
- 确定BAL淋巴细胞比例和CT纤维化程度的值,以预测PF的结果.
主要方法:
- 一个带有诊断BAL的PF患者的衍生队列接受了纤维化程度和UIP模式的CT评分.
- 招募了一个具有相同标准的前性验证队列.
- 多变量逻辑回归分析了BAL淋巴细胞比例,CT发现和一年内FVC减少或死亡之间的关联.
主要成果:
- BAL淋巴细胞比例,UIP模式和纤维化程度独立预测了衍生队列中的PF进展 (n=240).
- 确定了25%的BAL淋巴细胞比例和20%纤维化程度的值.
- 在患有UIP模式 (5.9%) 或广泛纤维化 (4.9%) 的患者中,BAL淋巴细胞增多不常见.
- 在验证队列 (n=290) 中,高BAL淋巴细胞比例与非UIP模式或有限纤维化患者的进展风险较低相关.
结论:
- 在患有广泛纤维化或CT上UIP模式的PF患者中,BAL淋巴细胞瘤不常见.
- 在没有UIP模式或有限纤维化的患者中,BAL淋巴细胞比例≥25%表明PF进展的可能性降低.
关键词:
BALAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL BAL计算机断层扫描 (CT) 是一种计算机断层扫描.淋巴细胞化的淋巴细胞.肺部纤维化 肺部纤维化通常的间歇性肺炎.更多相关视频
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