Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

1.3K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.3K
Location and Orientation of the Heart01:13

Location and Orientation of the Heart

3.0K
The human heart, despite its modest size and weight, is an organ of remarkable strength and endurance. Roughly the size of a fist, the heart weighs between 250 and 350 grams and is nestled within the mediastinum, the medial cavity of the thorax. It extends obliquely for about 12 to 14 cm, resting on the superior surface of the diaphragm. The heart is positioned anterior to the vertebral column and posterior to the sternum, with two-thirds of its mass lying to the left of the midsternal line.
3.0K
Heart Valves01:16

Heart Valves

4.8K
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
4.8K
Overview of the Heart01:07

Overview of the Heart

6.0K
The heart, a muscular organ located in the chest, functions as the body's pump, circulating blood through the vascular system. It has four chambers: two atria on top and two ventricles below. The right atrium receives deoxygenated blood from the body and passes it to the right ventricle, which pumps it to the lungs for oxygenation. The left atrium receives oxygenated blood from the lungs and transfers it to the left ventricle, which pumps it to the rest of the body.
The heart's...
6.0K
Anatomy of the Heart01:27

Anatomy of the Heart

109.5K
The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
109.5K
Layers of the Heart Wall01:15

Layers of the Heart Wall

2.6K
The heart wall comprises three distinct layers: the epicardium, myocardium, and endocardium. The outermost layer, the epicardium, is the visceral layer of the serous pericardium, featuring a thin, transparent mesothelial surface and an inner layer of areolar connective tissue with fat deposits that increase with age.
The myocardium, the thickest layer, consists of cardiac muscle cells interconnected by intercalated discs and crisscrossing connective tissue fibers. These muscle fibers contract...
2.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Vitamin C Supplementation in Hospitalized Patients With Community-Acquired Pneumonia: Protocol for a Randomized Controlled Trial.

JMIR research protocols·2026
Same author

Oxidative Stress Biomarkers in Silicosis: A Systematic Review.

Diseases (Basel, Switzerland)·2026
Same author

Prevalence of multimorbidity and uptake of guideline-directed medicines for cardiovascular conditions in Australian hospitalised adults: a cross-sectional study.

BMJ open·2026
Same author

Clinical phenotypes of atrial fibrillation: A review of machine learning applications in personalized treatment.

JRSM cardiovascular disease·2025
Same author

Guideline-Concordant Antibiotic Treatment for Hospitalised Patients with Community-Acquired Pneumonia and Clinical Outcomes at a Tertiary Hospital in Australia.

Antibiotics (Basel, Switzerland)·2025
Same author

Evaluating medication discrepancies and harm: a matched cohort study of collaborative pharmacist prescribing in a statewide healthcare system using electronic prescribing.

International journal of clinical pharmacy·2025
Same journal

Non-canonical amino acid incorporation enables minimally disruptive labeling of stress granule and TDP-43 proteinopathy.

eLife·2026
Same journal

Analysis of dendritic input currents during place field dynamics.

eLife·2026
Same journal

TopoMetry systematically learns and evaluates the latent geometry of single-cell data.

eLife·2026
Same journal

Navigating the path: Advice to physician-scientists on choosing a clinical specialty.

eLife·2026
Same journal

Neural activity profiles reveal overlapping, intermingled subpopulations spanning area borders in mouse sensorimotor cortex.

eLife·2026
Same journal

The exquisite mechanics of a tsetse bite.

eLife·2026
查看所有相关文章

相关实验视频

Updated: Jul 17, 2025

Author Spotlight: Enhancing Donor Heart Preservation Through Isolated Rat Heart Perfusion Studies
06:56

Author Spotlight: Enhancing Donor Heart Preservation Through Isolated Rat Heart Perfusion Studies

Published on: October 4, 2024

538

保护心脏 保护心脏

Joshua M Inglis1,2, Arduino A Mangoni1

  • 1Department of Clinical Pharmacology, Flinders Medical Centre and Flinders University, Adelaide, Australia.

eLife
|September 6, 2023
PubMed
概括
此摘要是机器生成的。

阻止EPAC1蛋白可能会预防化疗引起的心脏问题. 这一发现提供了一种潜在的策略,可以在癌症治疗期间减轻心脏毒性.

关键词:
美国环保协会1 EPAC1癌症生物学 癌症生物学癌症的生存率 癌症的生存率心脏有毒性心脏有毒性细胞生物学 细胞生物学德克索鲁比辛 (doxorubicin) 是一种药物.人类 人类 人类 人类 人类 人类 人类这里是鼠标鼠标鼠标鼠标鼠标鼠标.鼠标 鼠标 鼠标 鼠标 鼠标

更多相关视频

Capturing the Cardiac Injury Response of Targeted Cell Populations via Cleared Heart Three-Dimensional Imaging
08:14

Capturing the Cardiac Injury Response of Targeted Cell Populations via Cleared Heart Three-Dimensional Imaging

Published on: March 17, 2020

6.0K
Murine Isolated Heart Model of Myocardial Stunning Associated with Cardioplegic Arrest
08:30

Murine Isolated Heart Model of Myocardial Stunning Associated with Cardioplegic Arrest

Published on: August 6, 2015

11.7K

相关实验视频

Last Updated: Jul 17, 2025

Author Spotlight: Enhancing Donor Heart Preservation Through Isolated Rat Heart Perfusion Studies
06:56

Author Spotlight: Enhancing Donor Heart Preservation Through Isolated Rat Heart Perfusion Studies

Published on: October 4, 2024

538
Capturing the Cardiac Injury Response of Targeted Cell Populations via Cleared Heart Three-Dimensional Imaging
08:14

Capturing the Cardiac Injury Response of Targeted Cell Populations via Cleared Heart Three-Dimensional Imaging

Published on: March 17, 2020

6.0K
Murine Isolated Heart Model of Myocardial Stunning Associated with Cardioplegic Arrest
08:30

Murine Isolated Heart Model of Myocardial Stunning Associated with Cardioplegic Arrest

Published on: August 6, 2015

11.7K

科学领域:

  • 心脏病学 心脏病学
  • 药理学 药理学是指药理学的学科.
  • 在瘤学瘤学.

背景情况:

  • 化疗药物可能会导致严重的心脏相关的副作用.
  • 蛋白质EPAC1 (由cAMP 1直接激活的交换蛋白) 与心血管功能有关.

研究的目的:

  • 调查阻断EPAC1是否可以预防化疗诱导的心脏毒性.
  • 探索一种潜在的治疗点来管理化疗副作用.

主要方法:

  • 利用临床前模型研究化疗对心脏的影响.
  • 研究了EPAC1在调解药物诱导的心脏损伤中的作用.
  • 评估了EPAC1抑制在预防这些副作用方面的有效性.

主要成果:

  • 化疗药物管理导致心脏功能障碍.
  • 发现EPAC1在这种功能障碍的发展中起着重要作用.
  • 阻断EPAC1有效地预防了化疗引起的心脏问题.

结论:

  • EPAC1是化疗诱导心脏毒性的关键调解者.
  • 准EPAC1是一种有希望的方法,可以在癌症治疗期间保护心脏.