在肥胖症中高血压的血管活性调解剂
Husam Ghanim1, Tina K Thethi2, Sanaa Abuaysheh1
1Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, United States.
American journal of physiology. Endocrinology and metabolism
|September 6, 2023
概括
肥胖与更高的血压有关,病态肥胖症显示血管收缩因子增加,如血管新生素II和内甲蛋白-1. 这项研究揭示了关键的血管活性调解剂,这些调解剂有助于肥胖个体的血压变化.
科学领域:
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 肥胖是高血压的重要危险因素,但潜在的机制仍然不完全理解.
- 血管活性介质在血压调节中起着至关重要的作用,并与高血压的病理生理学有关.
研究的目的:
- 研究由体重指数 (BMI) 定义的肥胖症与各种血管活性介质水平之间的关系.
- 探索这些介质如何与血压和其他人口因素相关.
主要方法:
- 一项涉及135名成年人进行的横截面研究,分为非肥胖,肥胖和严重肥胖的组.
- 血压 (BP) 的测量,包括静脉压 (SBP) 和静脉压 (DBP) 的测量,以及关键血管活性介质的量化 (例如,血管新生素II,内甲蛋白-1,BNP).
主要成果:
- 与非肥胖者相比,在肥胖和患有肥胖症的人群中观察到较高的SBP和DBP.
- 致病性肥胖症与血管新素II,内甲素-1 (ET-1) 和 neprilysin 的水平升高,以及大脑 natriuretic (BNP) 的水平降低有关.
- 体重指数与SBP,DBP,血管新生素II,ET-1和 neprilysin正相关,而与BNP和循环氨酸单酸盐 (cGMP) 则相反相关.
结论:
- 肥胖,特别是病态肥胖,与血管活性介质的显著改变有关,有利于血管收缩 (血管素II,ET-1) 和减少血管扩张 (BNP,cGMP).
- 这些介质变化导致肥胖个体血压升高.
- 血管活性介质包括血管素II,阿尔多素,素和ET-1部分解释了除了年龄,性别和种族等既定因素之外的静脉血压变化.
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