压缩性光神经病和正常张力玻璃眼中的周周血管密度:严重性控制的比较
Eun Jung Lee1, Jong Chul Han1, Changwon Kee1
1Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Investigative ophthalmology & visual science
|September 6, 2023
概括
压缩性视神经病变 (CON) 在患有类似的黄斑损伤的患者中显示出明显较低的周周血管密度 (VD),而不是正常张力玻璃眼 (NTG). OCT血管造影可以帮助区分这些疾病.
科学领域:
- 眼科医生 眼科 眼科
- 神经科学是一个神经科学.
- 医疗成像医学成像
背景情况:
- 压缩性视神经病变 (CON) 和正常张力玻璃眼 (NTG) 是不同的视神经病变.
- 评估微血管变化对于理解病原和诊断至关重要.
研究的目的:
- 为了比较CON和NTG之间的周血管密度 (VD).
- 调查OCT血管学 (OCTA) 在区分这些疾病的诊断效用.
主要方法:
- 追溯比较的患者与CON和NTG.
- 光学连贯断层扫描 (OCT) 检测视网膜神经纤维层 (RNFL) 和质细胞内状层 (GCIPL) 厚度.
- OCT血管造影 (OCTA) 检测周周毛囊和黄斑血管密度 (VD).
- 严格控制平均黄斑损伤 (GCIPL损伤).
主要成果:
- 与NTG组相比,CON组的周周膜性静脉疾病明显较低 (P < 0.001).
- 在调整年龄,折射误差,视野灵敏度,RNFL厚度,GCIPL厚度和图像质量后,这种差异仍然存在.
- 在CON中观察到部和鼻腔部门明显的VD损失.
结论:
- 与NTG患者相比,CON患者表现出明显较低的周囊性VD,即使RNFL和GCIPL损伤相似.
- 来自OCTA的VD可能有助于区分CON和NTG.
- 研究结果表明,CON和NTG之间的微血管妥协致病性可能存在差异.
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