批量和流量绿色微波辅助的催化转化Levulinic酸到pyrrolidones的催化转化
Emanuela Calcio Gaudino1, Maela Manzoli1,2, Maria Luisa Testa3
1Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, 10125, Turin, Italy.
ChemSusChem
|September 6, 2023
概括
这项研究引入了一种可持续的微波辅助方法,用于使用新型催化剂将氨酸转化为N替代的罗利. 该过程是高效的,可回收利用的,适合工业规模扩大,避免有毒溶剂.
科学领域:
- 绿色化学 绿色化学
- 催化剂是一种催化剂.
- 有机合成 有机合成
背景情况:
- 酸是从生物质中提取的关键平台化学物质.
- 开发可持续和高效的转化方法至关重要.
- 替代N的pyrrolidones具有各种工业应用.
研究的目的:
- 开发一种可持续的微波辅助催化协议,用于从氨酸中合成N替代型罗利.
- 为了研究新型单 (Pd,Au) 和双金属 (PdAu) 催化剂的有效性,这些催化剂是基于半孔二氧化 (HMS) 或胺添加剂的HMS.
- 优化批量和流量合成的反应条件,专注于绿色溶剂和可扩展性.
主要方法:
- 微波辅助 (MW-assisted) 降解性氨基化勒酸与各种氨基.
- 使用量身定制的Pd,Au和PdAu催化剂,支持HMS和化HMS (TiHMS).
- 在压下的批量模式中进行优化,然后在MW辅助流量反应堆中使用绿色溶剂,如环甲基以太 (CPME) 进行扩展.
主要成果:
- 在90分钟内在150°C下使用PdTiHMS和PdAuTiHMS催化剂在批量模式下获得了N替代型罗利的良好至优异产量.
- 催化剂在六个反应周期中表现出极好的可回收性和稳定性.
- 在流动模式下,使用PdTiHMS和CPME在150°C时获得了99%的N-(4-甲基) 罗利丁-2-产量.
结论:
- 开发的MW辅助流合成是一种安全,高效和可持续的协议,用于生产N替代型罗利.
- 使用新型支持的催化剂和绿色溶剂使该过程在工业上可行.
- 这种方法为传统合成方法提供了一个环保的替代方案,避免有毒的有机溶剂.
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