在患有唐氏综合征的儿童中,医疗成像利用和相关的辐射暴露
Emily C Marlow1, Jonathan M Ducore2, Marilyn L Kwan3
1Department of Surveillance & Health Equity Science, American Cancer Society, Kennesaw, Georgia, United States of America.
PloS one
|September 6, 2023
概括
患有唐氏综合征的儿童比同龄人接受的医学成像和辐射暴露要多得多,特别是在婴儿期. 这凸显了需要仔细考虑这个脆弱人群的成像实践的需要.
科学领域:
- 儿科放射学 儿科放射学
- 医学成像医学成像
- 辐射瘤学 辐射瘤学
背景情况:
- 患有唐氏综合征的儿童往往需要更多的医疗干预.
- 由于辐射敏感性增加,了解这一群体的辐射暴露至关重要.
研究的目的:
- 评估唐氏综合征儿童的医学成像和相关辐射暴露的频率.
- 为了比较患有唐氏综合征和没有唐氏综合征的儿童之间的成像率和辐射剂量.
主要方法:
- 对超过430万儿童 (1996-2016) 的回顾性队列研究.
- 包括3095名被诊断患有唐氏综合征的儿童.
- 每100人/年计算成像率和红骨髓剂量 (mGy).
- 使用过分散的波桑回归来估计相对率 (RR).
主要成果:
- 患有唐氏综合征的儿童的成像率更高:婴儿 (<1岁) 的成像率是9.5倍,老年儿童 (1-18岁) 的成像率是2.3倍.
- 具体的治疗方法显示,唐氏综合征儿童的患病率显著更高,包括血管造影 (RR=35.8) 和光镜 (RR=11.9).
- 唐氏综合征儿童的平均累积红骨髓剂量是唐氏综合征儿童的2倍 (4.7 mGy对 1.9 mGy).
结论:
- 患有唐氏综合征的儿童经历的医学成像和辐射暴露大大增加.
- 这种增加的暴露在年幼的儿童中尤为明显,因为他们更容易受到辐射的影响.
- 临床医生应采取战略管理决策,以对这一高风险儿科群体进行成像.
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