相关实验视频
Updated: Jul 17, 2025

08:16
Comparative Lesions Analysis Through a Targeted Sequencing Approach
Published on: November 5, 2019
6.8K
遗传变化的频率在已晚期乳腺癌中因转移部位而异
Isabel Grote1, Alexandra Poppe1, Ulrich Lehmann1
1Institute of Pathology, Hannover Medical School, Hannover, Germany.
Genes, chromosomes & cancer
|September 6, 2023
概括
转移性乳腺癌 (mBC) 根据转移部位表现出明显的遗传变化. 了解这些突变,如PIK3CA和TP53,可以帮助解释为什么癌症会扩散到特定的器官.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 癌症转移 癌症转移
背景情况:
- 20-30%的乳腺癌患者会发生远程转移.
- 转移性部位 (骨,肝脏,肺部,大脑) 通常是基于乳腺癌亚型的器官特异性.
- 关于乳腺癌转移部位及其遗传突变特征之间的关系的数据有限.
研究的目的:
- 为了研究乳腺癌转移的突变特征在常见的网站.
- 确定特定的遗传变化是否与转移部位相关.
- 探索突变对转移性乳腺癌中机体化的影响.
主要方法:
- 对来自骨,大脑,肝脏和肺部的521种乳腺癌转移的分析.
- 使用了下一代测序 (NGS) 和热测序.
- 评估了AKT1,ERBB2,ESR1,PIK3CA和TP53基因突变的发生频率.
主要成果:
- 在64%的病例中发现了体质突变;PIK3CA和TP53是最常见的.
- 与其他部位相比,TP53突变在大脑转移中显著高 (51.0%).
- 在肝脏 (40.6%),肺 (36.8%) 和骨 (35.7%) 转移中,PIK3CA突变很常见.
- 在肝脏和肺部转移中ESR1突变很普遍 (大约. 30%),但在大脑转移中很少发生 (2.0%).
结论:
- 在转移性乳腺癌中,根据受影响的器官存在突变状态的显著差异.
- 乳腺癌的突变特征可能会影响其转移到特定器官的倾向 (有机变).
- 这些发现有助于了解乳腺癌转移的机制.
相关概念视频
Tumor Progression
6.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.4K
Metastasis
5.6K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.6K
Cancers Originate from Somatic Mutations in a Single Cell
12.0K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
12.0K
Adaptive Mechanisms in Cancer Cells
5.8K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.8K

