可降解PDA@PNIPAM-TA纳米复合材料用于温度和NIR光控制的农药释放
Manting Wang1,2, Rongrong Fan1,2, Qingjian Yu1,2
1State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, P. R. China.
Langmuir : the ACS journal of surfaces and colloids
|September 6, 2023
概括
研究人员开发了智能微凝和纳米复合材料系统,用于控制农药的输送. 这些系统提供了增强的附着性,可调节的释放,由温度和光触发,并改善了对可持续农业的害虫控制.
科学领域:
- 材料科学 材料科学 材料科学
- 聚合物化学 聚合物化学
- 纳米技术纳米技术
- 农业科学 农业科学
背景情况:
- 传统的农药配方在有效性和环境影响方面存在局限性.
- 控制的农药输送系统在有针对性的释放和减少环境暴露方面具有优势.
- 响应环境刺激的智能材料对于先进的传送系统至关重要.
研究的目的:
- 为了准备可降解的聚N-异烯胺 (PNIPAM) -酸 (TA) 微凝和PDA@PNIPAM-TA纳米复合材料,用于智能化农药配送.
- 研究开发材料的刺激响应释放行为和叶状粘附性质.
- 为了评估纳米复合材料在不同的环境条件下提供伊米达克洛普里德 (IMI) 的有效性.
主要方法:
- 合成PNIPAM-TA微凝和PDA@PNIPAM-TA纳米复合材料使用高重力旋转包装床反应器 (RPB).
- 材料性质的表征,包括温度依赖的膨胀/脱水和pH诱导的降解.
- 动态接触角度测试用于叶子粘附度的评估和封装/释放研究的伊米达克洛普里德 (IMI).
主要成果:
- 微凝和纳米复合材料表现出可逆的温度依赖的膨胀/脱水和不可逆的pH诱导的降解.
- 引入TA和PDA增强了叶子粘附和沉积效率.
- IMI释放率与温度有显著的相关性 (23.5%在25°C对比81.2%在40°C),并被近红外 (NIR) 光增强.
结论:
- 开发的PNIPAM-TA和PDA@PNIPAM-TA系统提供了一种基于环境刺激的简单方法来控制农药释放.
- 可调节的热敏反应行为和增强的粘附性能使这些纳米复合材料成为智能农药输送的有希望的产品.
- 这项工作展示了高重力技术在创造有效和可持续的作物保护解决方案方面的潜力.
相关概念视频
Modified-Release Drug Delivery Systems: Rate-Programmed II
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Rate-Programmed I
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Microbial Bioremediation of Pesticides
Pesticides often feature structurally complex chemical architectures, incorporating halogen groups and multiple aromatic rings. These characteristics confer high chemical stability, rendering many pesticides resistant to natural degradation processes. This resistance poses significant environmental concerns, as persistent pesticide residues can accumulate in ecosystems and affect non-target organisms.Despite the inherent stability of many pesticides, certain microorganisms possess the metabolic...
Production of Biopesticides
Biopesticides offer a sustainable alternative to chemical pesticides, utilizing microbial agents to control agricultural pests. Bacillus thuringiensis (Bt) is a widely employed bacterium known for its potent insecticidal activity. Bt biopesticides are favored for their specificity to insect pests, minimal environmental impact, and natural degradability.Mechanism of Bt Toxin Action Bt produces insecticidal crystal (Cry) proteins during its sporulation phase. These proteins form parasporal...
Bioplastics
Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...


