接种BCG疫苗会诱导人类的 γδ T 细胞中的先天免疫记忆
Tsz K Suen1, Simone J C F M Moorlag2, Wenchao Li3,4
1Department of Molecular Immunology and Cell Biology, Life and Medical Sciences Institute, University of Bonn, Carl-Troll-Straße 31, 53115 Bonn, Germany.
卡尔梅特 - 格林杆菌疫苗诱导了人类马三角形T细胞的训练免疫力,增强了它们对无关感染的反应. 这一发现表明了疫苗的新机制.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 细胞生物学 细胞生物学
背景情况:
- 众所周知,Bacillus Calmette-Guérin (BCG) 疫苗可以诱导髓状细胞和自然杀手细胞的训练免疫力,从而促进对感染的交叉保护.
- 马三角 (γδ) T细胞表现出先天性和适应性免疫的特征,但它们在训练免疫力中的作用,特别是对BCG的反应,尚未完全理解.
研究的目的:
- 为了研究人类的 γδ T 细胞是否可以在Bacillus Calmette-Guérin疫苗接种后产生训练免疫力.
- 为了确定BCG诱导的γδ T细胞训练免疫力是否有助于疫苗对异种病原体的交叉保护作用.
主要方法:
- 在BCG接种后的健康人类志愿者中利用单细胞RNA测序和免疫功能测定.
- 分析了 γδ T 细胞转录程序的变化以及对各种刺激的反应,包括脂多糖和Candida albicans.
主要成果:
- 菌卡尔梅特-盖林疫苗接种并没有改变γδ T 细胞的总数或激活标志物.
- BCG疫苗接种诱导了γδ T细胞转录特征的显著变化.
- 接种疫苗的 γδ T 细胞对异种细菌和真菌刺激的反应性增加,由更高的 TNF-α 和 IFN-γ 生产证明.
结论:
- 人类的 γδ T 细胞在接种菌卡尔梅特-盖林疫苗后具有培训免疫表型的能力.
- 这种BCG诱导的,在γδ T细胞中的训练免疫力可能在疫苗对各种感染的广泛保护作用中发挥作用.
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