阿特佐利祖马布用于高级膜软部肉瘤
Alice P Chen1, Elad Sharon1, Geraldine O'Sullivan-Coyne1
1From the Division of Cancer Treatment and Diagnosis (A.P. Chen, E.S., G.O.-C., N.M., J.C.F., A.R.N., N.T., L.K.F., C.L.R., J.H.D.) and the Center for Cancer Research (J.G., J.H.D.), National Cancer Institute, Bethesda, the Clinical Pharmacodynamics Biomarker Program, Applied and Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick (K.K.F., B.L.M., D.F.W., A.B., K.V.F.-G., R.E.P.), and the Department of Oncology, Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore (B.H.L.) - all in Maryland; the Division of Oncology, University of Southern California Norris Comprehensive Cancer Center, Los Angeles (J.S.H.); the Division of Oncology, Washington University School of Medicine in St. Louis, St. Louis (B.A.V.T.); the University of Texas M.D. Anderson Cancer Center, Houston (A.P. Conley); Emory University, Atlanta (W.L.R.); Duke Cancer Institute, Duke University Medical Center, Durham, NC (R.F.R.); University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh (M.A.B.); the Division of Hematology-Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville (E.J.D.); the Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston (P.M.); the Department of Internal Medicine, Section of Medical Oncology, Yale University School of Medicine, New Haven, CT (H.A.D.); the Division of Hematology and Oncology, Department of Medicine, Columbia University Irving Medical Center, New York (G.K.S.); Mayo Clinic, Rochester, MN (S.H.O.); the Division of Pediatric Hematology-Oncology, University of Nebraska Medical Center, Omaha (J.C.B.); the Division of Medical Oncology, Department of Internal Medicine, Ohio State University, Columbus (J.L.C.); and Stephenson Cancer Center at the University of Oklahoma, Oklahoma City (A.R.N.).
阿特佐利祖马布在晚期膜软部肉瘤 (ASPS) 中表现有前途,这是一种罕见的癌症,没有标准治疗方法. 这项研究在约三分之一的患者中发现了持续反应,为ASPS治疗提供了新的希望.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 罕见的癌症 罕见的癌症
背景情况:
- 膜软部肉瘤 (ASPS) 是一种罕见的软组织肉瘤,预后不佳,没有确定的治疗方法.
- 免疫检查点抑制剂最近在ASPS患者中显示出令人鼓舞的反应.
研究的目的:
- 评估atezolizumab的疗效和安全性,一种抗编程死亡配体1 (PD-L1) 剂,在患有晚期ASPS的患者中.
主要方法:
- 一个2期,多中心,单组研究,涉及成人和儿科患者的高级ASPS.
- 阿特佐利祖马布每21天一次静脉注射一次.
- 使用RECIST v1.1标准评估了客观反应,反应持续时间和无进展生存期.
主要成果:
- 在52名患者中,客观反应在37%的患者 (1个完整反应,18个部分反应) 中被观察到.
- 响应的中位持续时间为24.7个月,中位无进展生存时间为20.8个月.
- 即使在治疗中断后,反应也持续,并且没有发生与治疗相关的4级或5级不良事件.
结论:
- 阿特佐利祖马布在约三分之一的晚期ASPS患者中证明了诱导持续反应的有效性.
- 这一发现表明,阿特佐利祖马布作为高级ASPS的潜在治疗选择.
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