率驱动的液体-液体相分离过渡到聚合物微粒.
Morteza Rasoulianboroujeni1, Melgardt M de Villiers1, Glen S Kwon1
1Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin, 777 Highland Avenue, Madison, Wisconsin 53705, United States.
The journal of physical chemistry. B
|September 6, 2023
概括
使用寡合物作为溶剂的透驱动液态-液态相分离 (LLPS) 为聚合物微粒形成提供了可调的前体. 这种可逆的过程允许对两系统的自我组装进行控制.
科学领域:
- 材料科学 材料科学 材料科学
- 物理化学 物理化学
- 聚合物科学 聚合物科学
背景情况:
- 液-液相分离 (LLPS) 越来越多地被认为是两性系统中自组装的前体.
- 控制LLPS是理解和指导自组装过程的关键.
研究的目的:
- 建议和建模使用驱动的LLPS作为聚合物微粒形成的可调性前体.
- 调查溶剂寡合化对LLPS和化行为的影响.
主要方法:
- 使用平均场格子理论开发一个综合模型.
- 预测LLPS和化条件.
- 使用动态光散射和相位显微镜进行实验验证.
主要成果:
- 溶剂的聚合度显著影响相位行为,超过了体贡献.
- 模型预测LLPS在特定块共聚合物 (例如PEG4kDa-b-PLA2.2kDa) 的化前与聚合度≥5.5的溶剂进行聚合.
- 实验结果证实了对PEG4kDa-b-PLA2.2kDa/PEG200/水混合物的模型预测,显示在特定含水量时的LLPS和化.
结论:
- 由透驱动的LLPS提供了一个可调节的通路,用于聚合物微粒形成.
- 从LLPS到微粒的过渡是可逆的,这表明相隔液体和微粒之间存在热力学平衡.
- 寡合体溶剂提供了一种新的方法来控制区块共聚合物系统的自我组装.
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