从病例控制研究中探索有机紫外线过器对儿童的环境肥胖效应
Beili Wang1, Yihui Jin1, Juan Li2
1State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Chemosphere
|September 6, 2023
概括
有机紫外线过器是与儿童肥胖相关的新兴污染物. 暴露于EHMC可能是女孩的肥胖原体,而紫外线过器混合物显示与儿童肥胖有负面关联.
科学领域:
- 环境健康 环境健康
- 儿科内分泌学 儿科内分泌学
- 毒理学 毒理学 毒理学
背景情况:
- 儿童肥胖是一个重要的全球公共卫生问题.
- 有机紫外线 (UV) 过器是新出现的污染物,关于它们与儿童肥胖相关的数据有限.
- 了解紫外线过器的暴露风险对于公共卫生干预至关重要.
研究的目的:
- 研究8种有机紫外线过器在尿液中的含量与中国儿童的儿童肥胖之间的关联.
- 识别特定的紫外线过器,这些过器可能作为环境肥胖原体.
- 用统计模型评估紫外线过器混合物对儿童肥胖的影响.
主要方法:
- 在284名肥胖和220名非肥胖中国儿童的尿样中分析了8种有机紫外线过器 (PABA-E,EHS,HMS,EHMC,BP-3,IAMC,OC,4-MBC).
- 统计分析包括后勤回归和与人口统计和饮食因素的关联研究.
- 应用贝叶斯核机器回归 (BKMR) 和量子g计算 (qgcomp) 模型来评估混合效应.
主要成果:
- 在儿童的尿液中检测到八种有机紫外线过器,在这个人群中首次检测到PABA-E,HMS,IAMC和OC.
- 尿液中EHMC度与女孩的肥胖有积极联系 (调整后OR=2.642).
- 尿中的OC度与女孩的肥胖有负面关联 (调整后OR=0.022).
- 无论是BKMR和qgcomp模型,都表明紫外线过器混合物与儿童肥胖之间存在负面关联.
结论:
- 暴露于EHMC可能会在女孩中起到环境肥胖的作用.
- 这项研究强调了有机紫外线过器作为儿童肥胖的潜在作用.
- 需要进一步的研究来阐明紫外线过器对儿童肥胖的个人和综合影响.
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