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2018年墨西哥南部和东部成年人暴露于亚拉托克辛:一项描述性研究

Adriana Monge¹, Martín Romero², John D Groopman³

¹Center for Research on Population Health, National Institute of Public Health, Cuernavaca, Mexico.

International journal of hygiene and environmental health

|September 6, 2023

概括

非洲毒素B1-lysine adduct (AFB1-lys) 暴露在墨西哥很普遍,特别是在Veracruz,农村地区,以及男性和较低社会经济群体中. 这一发现突出了针对肝细胞癌 (HCC) 预防策略的关键人群.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
癌症流行病学癌症流行病学

背景情况:

肝细胞癌 (HCC) 是一个重要的全球健康问题.
阿弗拉托xin B1-lysine adduct (AFB1-lys) 是一个经过验证的生物标志物和HCC的风险因素.
墨西哥东部和南部是潜在高水平的亚拉托克辛暴露区域.

研究的目的:

量化墨西哥东部和南部成年人中AFB1-lys暴露的患病率和水平.
确定与AFB1-lys水平相关的人口和地理因素.
为预防HCC提供公共卫生干预信息.

主要方法:

血清样本使用质谱分析分析了AFB1-lys.
研究了来自墨西哥五个州的952名成年人 (加权N=7,493,354) 的代表性样本.
统计分析包括检测频率,中位数和子组比较.

主要成果:

在91.9%的研究人群中检测到AFB1-lys.
中位数AFB1-lys水平为0.172 pg/μL.
在维拉克鲁兹,男性,老年人,农村地区和较低社会经济地位的人群中观察到更高的水平.

结论:

在研究的墨西哥人口中,AFB1-lys暴露非常普遍.
特定的子群体 (Veracruz,男性,农村,低SES) 呈现出明显更高的暴露水平.
了解这些暴露模式对于制定有针对性的HCC预防策略至关重要.

关键词:

阿弗拉托克素B1lysine添加物通过饮食的暴露.分子流行病学分子流行病学

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