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耐药粉通过肠道微生物组的改变降低了NAFLD患者的肝内甘油三
Yueqiong Ni1, Lingling Qian2, Sara Leal Siliceo3
1Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China; Microbiome Dynamics, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Beutenbergstraße 11A, 07745 Jena, Germany; Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena, Jena, Germany.
耐性粉 (RS) 补充剂在非酒精性脂肪肝 (NAFLD) 患者中有效降低了肝内甘油三. 这种饮食干预改善了肠道微生物群和血清分支链氨基酸,为NAFLD管理提供了潜在的策略.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 非酒精性脂肪肝 (NAFLD) 是与代谢功能障碍相关的日益严重的健康问题.
- 目前对NAFLD的有效治疗方法仍然有限,需要新的治疗方法.
研究的目的:
- 评估耐药粉 (RS) 作为用于治疗NAFLD的微生物群导向食补充剂的疗效.
- 研究RS对肝脏内甘油三含量 (IHTC),肠道微生物群和代谢标记物的影响.
主要方法:
- 一个为期4个月的随机化安慰剂控制的临床试验,涉及被诊断患有NAFLD的个人.
- 将临床试验数据与元基因组学和代谢组学分析结合起来.
- 采用了多项综合性分析,并在小鼠模型中验证了研究结果 (便微生物种移植和单一殖民).
主要成果:
- 与安慰剂相比,抗性粉 (RS) 的干预导致肝脏内甘油三含量 (IHTC) 绝对显著降低9.08%.
- 即使在调整体重减轻后,RS补充剂也显示IHTC减少了5.89%.
- 摄入RS显著减少了血清分支链氨基酸 (BCAA) 和改变了肠道微生物组成,特别是减少了Bacteroides stercoris,与IHTC和肝酶相关联.
结论:
- 耐性粉 (RS) 补充剂显示出作为治疗非酒精性脂肪肝疾病 (NAFLD) 的治疗策略的潜力.
- RS通过调节肠道微生物群的组成和功能来影响NAFLD的进展,影响BCAA的可用性和肝硬化.
- 这些发现支持RS作为对NAFLD的微生物群导向的饮食干预措施.
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