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手术前的普雷加巴林可以预防苏奇尼尔胆诱导的结和肌痛:随机试验的元分析
P A Vélez1, V Lara-Erazo2, A F Caballero-Lozada1
1Department of Anesthesiology, Universidad del Valle, Cali, Colombia.
Revista espanola de anestesiologia y reanimacion
|September 6, 2023
概括
gabapentinoids 有效地预防因顺胆引起的肌痛,这是这种肌肉放松剂的常见副作用. 这一系统性审查没有发现对带的显著影响,强调了它们在减少术后疼痛方面的好处.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 苏奇尼尔胆是一种广泛使用的神经肌肉阻断剂,用于快速序列诱导.
- 它的管理经常与不良反应有关,包括肌肉结和肌痛.
- 缓解这些副作用的有效策略在临床上很重要.
研究的目的:
- 系统地审查和对随机对照试验进行元分析,评估 gabapentinoids 预防因顺胆诱导的肌痛和结.
- 评估 gabapentinoids 在减少这些不良事件的发生率方面的有效性.
主要方法:
- 随机对照临床试验的系统审查和元分析.
- 包括的研究比较了 gabapentinoids (gabapentin,pregabalin) 和安慰剂.
- 分析了涉及481名患者的6项试验的数据.
主要成果:
- gabapentinoids 显著降低了顺胆诱导肌痛的发生率 (RR=0.69,P<.001).
- 普雷加巴林 (RR=0.71,P=.013) 和 gabapentin (RR=0.61,P=.001) 两种药物都单独显示出显著的减少.
- 在 gabapentinoid 和安慰剂组之间的结发生率没有显著差异 (RR=0.92,P=.148).
结论:
- 手术前使用 gabapentinoids 与手术后24小时内基尼尔胆诱导肌痛的发病率较低有关.
- gabapentinoids 有效预防因顺胆引起的肌痛,但不能预防结.
- 这表明 gabapentinoids 在需要顺胆的程序后增强患者舒适性方面发挥了宝贵的作用.
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