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作为癌症治疗的潜在目标,PAICS将纯素生物合成与癌症进展联系起来

Anqi Huo¹, Xiangyang Xiong²

¹Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Nanchang University, Nanchang, Jiangxi 330006, China; The First Clinical Medical College, Nanchang University, Nanchang, Jiangxi 330031, China.

|September 6, 2023

概括

癌细胞重编程新陈代谢,过度生产核酸. 酶PAICS驱动这种 purin 合成,促进瘤生长和转移,使其成为潜在的抗癌标.

科学领域:

生物化学生物化学
在瘤学瘤学.
分子生物学分子生物学

背景情况:

瘤细胞表现出代谢重编程,其特点是过度的核酸合成,这对于增殖和进展至关重要.
癌细胞和瘤微环境 (TME) 中核酸和代谢物水平的增加促进了瘤的发展.
新型 purin 合成是癌症中关键的代谢途径,使其酶成为有吸引力的治疗点.

研究的目的:

在癌症中审查氧化胺胺酶/氧化胺胺胺合成酶 (PAICS) 的结构,生物功能和分子机制.
讨论PAICS作为抗瘤疗法的治疗点的潜力.

主要方法:

文献综述总结了关于癌症PAICS的现有研究.
分析PAICS在 de novo purin 合成中的作用及其对癌细胞信号通路的影响.

主要成果:

PAICS是一种对新型 purin 合成至关重要的双功能酶,催化该途径的关键步骤.
增加PAICS表达与各种癌症的预后不佳相关.
通过调节PKM2,ERK1/2和FAK等途径,PAICS及其产品SAICAR可以促进瘤生长,抑制亡,并驱动上皮质-介质细胞过渡 (EMT),入侵和转移.

结论:

通过其参与核酸合成和关键信号通路的调节,PAICS在癌症进展中发挥着重要作用.
针对PAICS提出了一种有前途的治疗策略,用于打击各种类型的癌症.

关键词:

致癌的发生是致癌的产生.在新的 purin 合成中.核酸代谢的核酸代谢支付费用 (PAICS) 是一个费用.萨卡尔 (saicar) 是一种象牙.

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