交感神经系统促进肝淋巴细胞生成,这对抗肝纤维化有保护作用
Masatake Tanaka1, Jain Jeong2, Courtney Thomas3
1Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut; Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
The American journal of pathology
|September 6, 2023
概括
交感神经驱动肝脏中的淋巴血管生成,增加淋巴血管的形成. 这一对于肝脏健康至关重要的过程,似乎对肝纤维化进展有保护作用.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 血管生物学 血管生物学
- 神经科学是一个神经科学.
背景情况:
- 肝脏是最大的淋巴产生器官.
- 在肝硬化患者中,淋巴生产和淋巴血管生成增加.
- 肝纤维化中肝淋巴血管生成的机制和影响尚未完全理解.
研究的目的:
- 为了研究肝脏中淋巴血管生成的机制.
- 为了确定淋巴血管生成在肝纤维化中的作用.
- 探索交感神经和肝脏淋巴血管生成之间的关系.
主要方法:
- 与对照组相比,分析了患有门高血压和肝硬化症的患者的肝脏活检.
- 使用部分门静脉绑定 (PPVL) 和胆管绑定 (BDL) 的老鼠模型进行机制研究.
- 基因表达分析的公共数据集 (GSE77627) 从正常的,非肝硬化门高血压,肝硬化肝脏.
- 评估血管内皮生长因子-C (VEGF-C) 表达和VEGF-C中和或交感性皮化的影响.
主要成果:
- 淋巴细胞形成显著增加的肝脏从患者的门侧鼻血管疾病,肝硬化,和PPVL和BDL大鼠模型.
- 在PPVL大鼠中,交感神经的施万细胞具有高度表达的VEGF-C.
- 阻断VEGF-C或化减少了淋巴血管生成,导致肝纤维化恶化.
- 在肝硬化患者中,同情神经/施瓦恩细胞存在与淋巴血管数量之间观察到正相关性.
结论:
- 交感神经促进肝淋巴血管发生在非肝硬化和肝硬化肝脏.
- 由交感神经驱动的肝淋巴血管生成增加,可以保护肝纤维化.
- 准交感神经淋巴轴可能为肝纤维化提供治疗潜力.
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