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Updated: Jul 17, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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Published on: February 20, 2018

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GPR114/ADGRG5是由其绑定激动剂激活的,因为它是一个分裂粘附的GPCR

Tyler F Bernadyn1, Alexander Vizurraga1, Rashmi Adhikari1

  • 1Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA.

The Journal of biological chemistry
|September 6, 2023
PubMed
概括

像GPR114这样的粘附G蛋白结合受体 (AGPCR) 经历自我分裂,这对于它们的激活至关重要. 这项研究证实了GPR114的裂变及其在Gs蛋白信号传递中的作用,特别是在色素细胞中.

关键词:
在ADGRG5中,ADGRG5是什么?获利的域名域名是GAIN.粘附性G蛋白结合受体 (AGPCR) 的研究.自体蛋白质溶解是自体蛋白质溶解的过程.循环AMP (cAMP) 的使用.作为一个 orthosteric 激活剂.受体激活受体的激活方式结合激素激动剂的结合激动剂.

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