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tRNA衍生小RNA和其他调控性小RNA的新兴功能原理

Qi Chen¹, Tong Zhou²

¹Molecular Medicine Program, University of Utah School of Medicine, Salt Lake City, Utah, USA; Division of Urology, Department of Surgery, University of Utah School of Medicine, Salt Lake City, Utah, USA; Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA.

The Journal of biological chemistry

|September 6, 2023

概括

超出RNAi机制的调节性小非编码RNA (sncRNAs) 通过类似于aptamer的3D结构起作用. 这些古老的sncRNA功能,早于RNA干扰,为生物过程和治疗应用提供了新的见解.

科学领域:

分子生物学分子生物学
遗传学是一个遗传学.
生物化学生物化学

背景情况:

小RNA测序揭示了超越微RNA,siRNA和piRNA的多种调节性小非编码RNA (sncRNA).
这些sncRNAs来自tRNA,rRNA和snoRNA等各种结构化的RNA,具有未知的功能潜力.

研究的目的:

讨论新出现的sncRNAs的功能原理,它们独立于序列互补性而运作.
探索sncRNAs的体样功能及其进化含义.
提出重新评估RNAi起源及其与体样sncRNA功能的关系.

主要方法:

文献综述和对小型非编码RNA的当前研究的综合.
超越线性序列互补性的功能机制的分析.
在不同物种中对RNAi和aptamer类功能的比较分析.

主要成果:

发现了来自各种较长结构RNAs的多样化的sncRNAs宇宙.
在sncRNA中识别像aptamer的功能,依靠3D结构来进行连接体相互作用.
有证据表明,像阿普坦体这样的功能可能代表着一个早于RNAi的古老机制.

结论:

类似aptamer的sncRNA功能广泛存在,可能代表着一个古老的生物原理.
根据这些类似于aptamer的功能,重新思考RNAi的起源是必要的.
像aptamer的sncRNAs的非序列特异性需要在研究和治疗中谨慎使用小RNA模拟器.

关键词:

在此之前,AGOGO.潘多拉-第二节基因组RNA的修饰是RNA的修饰.结构 RNA 结构 RNA 结构它们是YRNA和YRNA.一个aptamer的应用程序.rRNARNArRNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNARNA 小小的RNARNA小小的RNARNA.这是一个 snRNA.斯诺RNA 斯诺RNA 是一种这是一个tRNARNA.收藏室RNARNA的存储库

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