通过肌肉内注射Bothrops leucurus毒液诱导的功能和结构变化
Paloma Santos Hora1, Joaquim Roque de Jesus Nogueira Junior2, Ricardo David Couto3
1Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Vitória da Conquista, Bahia, 45029094, Brazil.
Toxicon : official journal of the International Society on Toxinology
|September 6, 2023
概括
在老鼠模型中,Bothrops leucurus蛇毒会导致严重的损伤,包括功能下降和炎症增加. 这项研究强调了这种毒素的毒性,这与临床蛇病例有关.
科学领域:
- 毒理学 毒理学 毒理学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 类学 类学 类学 类学
背景情况:
- 急性损伤 (AKI) 是Bothrops蛇咬伤受害者死亡的主要原因.
- 关于Bothrops leucurus毒素对的特定影响的研究有限,特别是在肌肉内毒化后.
研究的目的:
- 为了研究Bothrops leucurus毒液在肌肉内注射后的毒作用.
- 在Wistar鼠模型中分析毒液对功能和组织学的影响.
主要方法:
- 威斯塔鼠被肌肉内注射了B. leucurus毒液 (1 mg/kg) 或盐水 (对照组).
- 通过测量血清和尿液中的肌素,白素,和水平,并计算膜过率 (GFR) 来评估功能.
- 在注射后72小时评估组织学和巨细胞透.
主要成果:
- B. leucurus毒液诱导了236%的血清肌酸激酶活性增加.
- 在暴露于毒素的组中,脏重量增加了26% (右) 和22% (左).
- GFR降低了37%,并且在被毒化的老鼠的脏中观察到显著的管间隙病变和增加的巨细胞透.
结论:
- 在肌内注射疫苗后,Bothrops leucurus的毒液会导致大量的组织学和功能性损伤.
- 这些发现与了解和管理Bothrops蛇咬伤的临床病例有关.
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