乳腺的罗莎-多夫曼病:一个临床放射学和病理学研究
Qun Wang1, Kyle Bradley1, Meng Zhang2
1Department of Pathology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Human pathology
|September 6, 2023
概括
乳腺的Rosai-Dorfman病 (RDD) 是一种罕见的疾病,可以模仿其他乳腺质量. 组织病理学证实了诊断,完全切除为乳腺RDD患者提供了很好的预后.
科学领域:
- 组织病理学 组织病理学
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 罗莎-多尔夫曼病 (RDD) 是一种罕见的囊细胞性疾病,很少影响乳房等节外部位.
- 乳腺RDD可以呈现为质体,模仿良性和恶性乳腺病变,使诊断复杂化.
- 准确的区分对于适当的患者管理和预后至关重要.
研究的目的:
- 描述7名患有乳腺罗莎-多夫曼病的患者的临床放射学和病理学特征.
- 讨论乳腺RDD的差异诊断,强调关键诊断标记.
- 评估乳腺RDD患者的治疗结果和预后.
主要方法:
- 七名被诊断患有乳腺RDD的患者的回顾性审查.
- 对临床放射学发现的分析,包括成像特征和BI-RADS分类.
- 通过免疫组织化学染色 (CD68,CD163,S100,OCT2,Cyclin D1,CK AE1/AE3,CD1a,BRAF V600E) 和辅助研究 (流细胞计,现场杂交,AFB,GMS染色) 的组织病理学检查.
主要成果:
- 七名患者 (15-74岁) 呈现单边 (5/7) 或双边 (2/7) 乳腺质量 (8-31毫米),分类为BI-RADS 4 (6/7) 或5 (1/7).
- 组织病理学揭示了具有特征的大型囊细胞与emperipolesis,纤维化和淋巴细胞透.
- 免疫组织化学显示CD68/CD163,S100,OCT2和Cyclin D1的共同表达,对CK AE1/AE3,CD1a和BRAF V600E具有负面影响. 辅助研究排除了淋巴瘤,IgG4相关疾病和感染.
结论:
- 乳腺RDD必须在乳腺质量的差异诊断中考虑,特别是那些具有暗示恶性瘤的成像.
- 准确的诊断依赖于将临床放射学发现与组织病理学和特定免疫组织化学标志物的整合.
- 完全切除乳腺RDD的手术导致了优秀的预后,没有报告的复发或进展到全身性疾病.
关键词:
乳腺成像报告和数据系统 (BI-RADS)流动细胞计量流动细胞计量免疫组织化学 免疫组织化学卡帕/兰布达在现场杂交.罗莎伊-多夫曼病 (Rosai-Dorfman disease) 是一种可怕的疾病.更多相关视频
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