在青春期早期内化,外化和思维障碍中的常见和疾病特异性皮质厚度变化:青少年大脑和认知发展研究
Gechang Yu1, Zhaowen Liu1, Xinran Wu1
1From the Institute of Science and Technology for Brain Inspired Intelligence, Fudan University, Shanghai, China (Yu, Wu, Fan, Peng, Kuang, Kang, Dong, Zhao, Feng, Sahakian, Robbins, Zhang); the Key Laboratory of Computational Neuroscience and Brain Inspired Intelligence, Fudan University, Ministry of Education, China (Yu, Wu, Fan, Peng, Kuang, Feng, Zhang); the Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Mass., USA (Liu); the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Mass., USA (Liu); the Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Mass., USA (Liu); the Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China (Becker); the School of Computer Science and Technology, East China Normal University, Shanghai, China (Zhang); the Shanghai Center for Mathematical Sciences, Fudan University, Shanghai, China (Kang); the MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China (Dong, Zhao); the Zhangjiang Fudan International Innovation Center, Shanghai, China (Zhao); the PONS Centre Shanghai, Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China (Schumann); the PONS Centre Berlin, Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charitéplatz 1, Berlin, Germany (Feng); the Shanghai Center for Mathematical Sciences, Shanghai, China (Feng); the Department of Computer Science, University of Warwick, Coventry, UK (Feng); the Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China (Feng); the Fudan ISTBI-ZJNU Algorithm Centre for Brain-inspired Intelligence, Zhejiang Normal University, Jinhua, China (Feng); the Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Cambridge, UK (Sahakian); the Department of Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK (Robbins); the Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Que., Canada (Palaniyappan); the Department of Psychiatry, Schulich School of Medicine and Dentistry, Western University, London, Ont., Canada (Palaniyappan); the Robarts Research Institute, Western University, London, Ont., Canada (Palaniyappan); the Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, Ont., Canada (Palaniyappan).
青少年的外部化和内部化障碍显示出不同的大脑皮层厚度模式和发育轨迹,表明了特定的神经生物学机制. 这些发现支持重新分组的方法来理解青年心理健康.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 遗传学 是一个遗传学.
背景情况:
- 神经成像研究揭示了成人精神障碍中常见的神经异常.
- 青春期明显的疾病特异性机制仍然不清楚,尽管观察到重叠.
研究的目的:
- 调查疾病特异性皮质厚度 (CT) 变化和青春期前儿童的发育轨迹.
- 为了确定这些独特的神经模式的遗传基础.
主要方法:
- 分析了来自青少年大脑和认知发育队列的11000多名儿童 (9-10岁).
- 重组方法在健康对照中比较皮质厚度,外部化,内部化和思维障碍组.
- 全基因组关联研究 (GWAS) 关于欧洲青年地区CT.
主要成果:
- 外化和内化障碍显示区域CT增加,特别是在左侧关节.
- 观察到独特的CT变化:体感/听觉皮质在外部化疾病中,运动/视觉区域在内部化疾病中.
- 外向化疾病显示皮质稀释减缓;GWAS确定了59种显著的遗传变异. 与特定的神经元类型相关的CT差异.
结论:
- 关于CT特异性的证据,发育轨迹,以及青春期早期外化和内化障碍的遗传因素.
- 支持重组方法在临床实践中的神经生物学有效性.
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