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Updated: Jul 17, 2025

Tyramide Signal Amplification for the Immunofluorescent Staining of ZBP1-Dependent Phosphorylation of RIPK3 and MLKL After HSV-1 Infection in Human Cells
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结构表明,E3结合酶XIAP的BIR2域通过RIPK2激酶二聚体接口结合

Mathilde Lethier1, Karine Huard1, Michael Hons1

  • 1European Molecular Biology Laboratory, Grenoble, France.

Life science alliance
|September 6, 2023
PubMed
概括

受体相互作用蛋白激酶2 (RIPK2) 对于NOD信号传输至关重要. 结构研究揭示了XIAP BIR2结合如何抑制RIPK2,澄清了其在炎症性疾病无处不在的支架作用.

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