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怀孕期间接种流感疫苗的安全性:系统审查

Dianna M Wolfe¹, Deshayne Fell², Chantelle Garritty¹

¹Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

|September 6, 2023

概括

怀孕期间接种季节性流感疫苗没有与不良分娩结果或母亲严重不良事件 (SAE) 的关联. 建议进行进一步的研究,以更好地控制偏见,以加强证据的确定性.

科学领域:

产科和妇科产科和妇科
免疫学免疫学免疫学
公共卫生公共卫生

背景情况:

建议在怀孕期间接种流感疫苗,以保护母亲和婴儿.
仍然担心潜在的不良分娩结果和母亲的严重不良事件 (SAE).
需要进行系统审查,以综合这些关联的现有证据.

研究的目的:

评估在怀孕期间接种流感疫苗和不良分娩结果之间的关联.
评估产前流感疫苗接种与母亲非产科性SAE之间的联系.
在现有证据中考虑混和时间偏差.

主要方法:

通过全面的数据库搜索 (Ovid MEDLINE ALL,Embase,Cochrane CENTRAL) 确定的观察性研究的系统审查,截至2021年6月.
排除对活体减弱疫苗,单臂队列和仅摘要的出版物的研究.
在数据允许的情况下,对特定结果进行双重元分析,使用推,评估,开发和评估 (GRADE) 方法评估证据确定性.

主要成果:

包括63项研究;29项专注于季节性流感疫苗接种与不接种疫苗.
分析显示,季节性流感疫苗接种与早产,自发流产或孕期婴儿出生之间没有显著的关联.
描述性摘要没有发现与死亡出生,先天异常或母亲非产科SAEs风险增加的显著关联.

结论:

目前的证据,虽然确定性很低,但表明在怀孕期间接种季节性流感疫苗与不良出生结果或母亲的SAEs无关.
在研究中对混和时间偏差的不一致控制限制了证据的强度.
未来的研究应该优先考虑强大的方法,以最大限度地减少偏见并提高研究结果的可靠性.

关键词:

流行病学流行病学免疫学免疫学感染控制的方法是感染控制.公共卫生公共卫生

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