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在鼻癌的脊椎动脉节省体积调制弧线治疗

Szu-Huai Lu¹, Hao-Ting Lan¹, Yi-Chun Tsai²

¹Division of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, Taipei, 100, Taiwan.

Medical dosimetry : official journal of the American Association of Medical Dosimetrists

|September 6, 2023

概括

节省脊椎动脉 (VA) 的体积调制弧线疗法 (VMAT) 在鼻癌患者中显著降低了这些关键血管的辐射剂量. 这种技术保持了治疗的有效性,同时保护长期幸存者免受血管并发症.

科学领域:

辐射瘤学辐射瘤学
医学物理医学物理
血管外科血管外科

背景情况:

血管狭窄是鼻癌的放射治疗后的一个严重的晚期并发症.
脊椎动脉 (VAs) 对于后部循环至关重要,可以受到辐射的影响.
保护VA对于长期幸存者的生活质量至关重要.

研究的目的:

评估节省脊椎动脉 (VA) 的体积调制弧线疗法 (VMAT) 技术的可行性.
评估在鼻癌患者中节省VA的剂量计影响.
为了确定VA-节约VMAT是否可以减少对脊椎动脉的辐射剂量,而不会影响治疗疗效.

主要方法:

在TrueBeam线性加速器上接受VMAT治疗的20名鼻癌患者被追溯分析.
原始的VMAT计划 (没有VA轮) 与新的VA节省VMAT计划进行了比较.
配对的t测试被用来比较两个规划技术之间的剂量参数.

主要成果:

节省VA的VMAT计划实现了可比的目标覆盖率和对其他处于风险的器官的剂量.
观察到脊椎动脉辐射剂量的显著降低.
特定剂量指标显示显著下降:V35Gy从97%降至56%,V50Gy从67%降至35%,V63Gy从15%降至7%-10% (p < 0.001).

结论:

脊椎动脉 (VAs) 在放射治疗规划中应被确定为有风险的器官 (OAR).
具有故意VA节约的光子VMAT是一种有效的策略,可以显著降低VA的辐射剂量.
这种方法有望缓解鼻癌幸存者的晚期血管并发症.

关键词:

鼻癌是指鼻癌.辐射疗法辐射疗法脊椎动脉脊椎动脉是什么

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