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在结核病中,NAD (H) 稳态是由糖性髓状细胞介导的宿主保护的基础

Hayden T Pacl1, Krishna C Chinta1, Vineel P Reddy1

  • 1Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA.

Nature communications
|September 6, 2023
PubMed
概括

结核菌破坏骨髓细胞糖解通过耗尽NAD +,阻碍免疫力. NAD+前体尼古丁胺通过恢复这种代谢途径,显示出对结核病的治疗潜力.

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