在Penaeus vannamei中发现的新型阴离子密码体显示出抗微生物和抗癌活性
Amr Adel Ahmed Abd El-Aal1,2, Fairen Angelin Jayakumar1, Chandrajit Lahiri1,3
1Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, 47500, Bandar Sunway, Selangor, Malaysia.
Scientific reports
|September 6, 2023
概括
研究人员从太平洋白中发现了具有强大的抗微生物和抗癌特性的新型阴性密. 这些具有针对微生物和癌细胞的选择性活性,为抗药性提供了一种新的策略.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 基因组学就是基因组学.
背景情况:
- 密是所有生物体中发现的加密生物活性.
- 阴离子密体向微生物和癌细胞,提供独立于基因突变的潜在治疗途径.
研究的目的:
- 通过使用in silico方法识别具有抗微生物和抗癌活性的新型cationic密.
- 评估合成的密码体对微生物和癌细胞以及生物膜的疗效.
主要方法:
- 在太平洋白 (Penaeus vannamei) 的RNA-seq数据的体分析.
- 根据电荷和细胞透潜力选择五种阴离子密.
- 在体外合成和生物活性测定对微生物和癌症细胞系和生物膜.
主要成果:
- 鉴定了12个密码体,其中5个被选择用于合成和测试.
- 所有五种合成的密都表现出选择性的抗微生物和抗癌活性.
- 证明了抗生物膜的有效性和与细菌细胞膜的相互作用 (格拉姆阳性和阴性).
结论:
- 该研究提供了一个框架,用于从转录基因数据中发现新型阴性密码体.
- 已识别的密是对抗多药耐药微生物和癌症的替代疗法的有希望的候选者.
- 密码体提供一种不依赖突变的作用机制,对于克服抗性至关重要.
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